A Phase 1 Dose Escalation Study of Oral VX-708 in Healthy Participants

Status Completed

Clinical Trial Summary

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple ascending doses of VX-708 in healthy participants.

Clinical Trial Description

This clinical trial information was submitted voluntarily under the applicable law and, therefore, certain submission deadlines may not apply. (That is, clinical trial information for this applicable clinical trial was submitted under section 402(j)(4)(A) of the Public Health Service Act and 42 CFR 11.60 and is not subject to the deadlines established by sections 402(j)(2) and (3) of the Public Health Service Act or 42 CFR 11.24 and 11.44.). ;

Study Design

Related Conditions & MeSH terms

Acute Pain

Clinical Trial Details

NCT number	NCT05347394
Study type	Interventional
Source	Vertex Pharmaceuticals Incorporated
Contact
Status	Completed
Phase	Phase 1
Start date	April 8, 2022
Completion date	April 14, 2023

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04484610` - Appropriate Opioid Quantities for Acute Pain - Pharmacist Study	Phase 4
Recruiting	`NCT05054179` - Pecto-Intercostal Fascial Plane Block Catheter Trial for Reduction of Sternal Pain	Phase 2/Phase 3
Completed	`NCT04548635` - VR for Burn Dressing Changes at Home	Phase 2/Phase 3
Recruiting	`NCT05370404` - Prescribing vs. Recommending Over-The-Counter (PROTECT) Analgesics for Patients With Postoperative Pain:	N/A
Completed	`NCT06054945` - Clinical Impact of IPACK Block Addition to Suprainguinal Fascia Iliaca Block
Completed	`NCT03825549` - A Randomized Trial of Behavioral Economic Approaches to Reduce Unnecessary Opioid Prescribing	N/A
Completed	`NCT05995912` - Efficacy and Safety of Etoricoxib-tramadol Tablet in Acute Postoperative Pain	Phase 2
Recruiting	`NCT05589246` - Regional Analgesia in Combination With Cryoanalgesia to Prevent Acute Pain Following Nuss Procedure	N/A
Recruiting	`NCT05572190` - Evaluate the Safety and Pharmacokinetic Profile of ETR028 and ETR029 in Healthy Adult Subjects	Phase 1
Terminated	`NCT04716413` - Evaluating the Use of Sublingual Sufentanil in Patients With Suboxone Treatment	Phase 4
Active, not recruiting	`NCT03537573` - Provider-Targeted Behavioral Interventions to Prevent Unsafe Opioid Prescribing for Acute Pain in Primary Care	N/A
Not yet recruiting	`NCT06317844` - Examination of Psychological and Physiological Pathways Linking Gratitude and Pain	N/A
Withdrawn	`NCT02957097` - Gabapentin as a Pre-emptive Analgesic in Oral and Maxillofacial Surgical Procedures	Phase 4
Terminated	`NCT02599870` - Clinical Study to Evaluate Clinical Impact of PGx-Guided Treatment for Patients Undergoing Elective Spinal Surgical Procedures	N/A
Completed	`NCT02565342` - Interscalene Brachial Plexus Block to Treat Pain After Clavicular Surgery	Phase 4
Completed	`NCT02380989` - Integrative Ayurveda Healing Relieves Minor Sports Injury Pain	Phase 2
Completed	`NCT02984098` - 40% Orally Administered Dextrose Gel is More Effective Than 25% Dextrose	Phase 4
Completed	`NCT03107338` - Preventive Treatment of Pain After Dental Implant Surgery	Phase 4
Completed	`NCT02489630` - Low Dose Ketamine as an Adjunct to Opiates for Acute Pain in the Emergency Department	Phase 4
Completed	`NCT02817477` - Intranasal Ketamine for Acute Traumatic Pain	Phase 4