Preemptive Analgesia in Total Knee Arthroplasty

Status Completed

Clinical Trial Summary

Acute Pain is the most common early complication after total knee arthroplasty that caused delayed mobilization, demands of morphine, and higher operative cost. There were many researches that had been done in analgesia method to find the most effective analgesia, lowest side effect, and easy to apply. Preemptive analgesia of combined celecoxib and pregabalin were reported to give a promising outcome.

In a randomized, double blind controlled clinical trial, 30 subjects underwent surgery for total knee arthroplasty using 15-20mg bupivacaine 5% epidural anesthesia. All subjects were divided into three groups. First group was given celecoxib 400mg and pregabaline 150mg 1 hour before operation, second group was given celecoxib 200mg and pregabaline 75mg twice daily started from 3 days before operation, and the last group was given placebo. The outcome was measured with VAS, knee ROM, and post-operative mobilization

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Acute Pain

Clinical Trial Details

NCT number	NCT03523832
Study type	Interventional
Source	Fakultas Kedokteran Universitas Indonesia
Contact
Status	Completed
Phase	Phase 2
Start date	July 1, 2015
Completion date	December 31, 2016

View Details

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