Effect of Low Power Laser in Tooth Pain Modulation Caused by Irreversible

Status Completed

Clinical Trial Summary

Anxiety, pain and discomfort are common stressful situations that occur during the dentistry practice, especially in the urgency endodontic practice. Studies have concluded that low intensity laser therapy is effective in treating pain. However, most studies have reported the low intensity laser therapy in chronic pain, few studies have shown its application on acute pain and none have evaluated the low intensity laser´s analgesic effect in acute pain of the pulp inflammation. Since the pulp tissue has the peculiar characteristic to be surrounded by dentin, in acute pulpits, the inflammatory reaction is more complicated than usual. Furthermore, during the inflammatory process, sometimes anesthesia is not always completely effective. Thus, this present study aims to evaluate whether previous therapy with low intensity laser could, by its analgesic effect, promote greater comfort especially to this type of patient. 60 patients with acute pulpits pain will be selected to this study (randomized and double-blinded) and they will be divided in 4 groups:

Group 1 ( n=15) - Control Group; Group 2 (n=15) - Laser 1: 780 nanometers (nm); 40 milliwatts (mW); 4 seconds per point; 0.16 Joules/point; total irradiated points: 02; Group 3 (n=15) - Laser 2: 780nm; 40 mW; 40 seconds per point; 1.6 Joules/point, total irradiated points: 02; Group 4 (n=15) - Placebo group - Sham Laser Irradiation.

The pain will be evaluated by a visual analogue scale (VAS) in 3 different times: initial pain, pain immediately after and 15 minutes after interventions (laser irradiation, or sham laser irradiation). After that, patients with acute pulp irreversible inflammation will be submitted to conventional endodontic urgency treatment. Data concerning the need of complimentary local anesthesia will be also taken into account. Data of different groups and times will be statistically compared.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject)

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02169102
Study type	Interventional
Source	University of Sao Paulo
Contact
Status	Completed
Phase	N/A
Start date	February 2013
Completion date	October 2014

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04484610` - Appropriate Opioid Quantities for Acute Pain - Pharmacist Study	Phase 4
Recruiting	`NCT05054179` - Pecto-Intercostal Fascial Plane Block Catheter Trial for Reduction of Sternal Pain	Phase 2/Phase 3
Completed	`NCT04548635` - VR for Burn Dressing Changes at Home	Phase 2/Phase 3
Recruiting	`NCT05370404` - Prescribing vs. Recommending Over-The-Counter (PROTECT) Analgesics for Patients With Postoperative Pain:	N/A
Completed	`NCT06054945` - Clinical Impact of IPACK Block Addition to Suprainguinal Fascia Iliaca Block
Completed	`NCT03825549` - A Randomized Trial of Behavioral Economic Approaches to Reduce Unnecessary Opioid Prescribing	N/A
Completed	`NCT05995912` - Efficacy and Safety of Etoricoxib-tramadol Tablet in Acute Postoperative Pain	Phase 2
Recruiting	`NCT05589246` - Regional Analgesia in Combination With Cryoanalgesia to Prevent Acute Pain Following Nuss Procedure	N/A
Recruiting	`NCT05572190` - Evaluate the Safety and Pharmacokinetic Profile of ETR028 and ETR029 in Healthy Adult Subjects	Phase 1
Terminated	`NCT04716413` - Evaluating the Use of Sublingual Sufentanil in Patients With Suboxone Treatment	Phase 4
Active, not recruiting	`NCT03537573` - Provider-Targeted Behavioral Interventions to Prevent Unsafe Opioid Prescribing for Acute Pain in Primary Care	N/A
Not yet recruiting	`NCT06317844` - Examination of Psychological and Physiological Pathways Linking Gratitude and Pain	N/A
Withdrawn	`NCT02957097` - Gabapentin as a Pre-emptive Analgesic in Oral and Maxillofacial Surgical Procedures	Phase 4
Completed	`NCT02565342` - Interscalene Brachial Plexus Block to Treat Pain After Clavicular Surgery	Phase 4
Terminated	`NCT02599870` - Clinical Study to Evaluate Clinical Impact of PGx-Guided Treatment for Patients Undergoing Elective Spinal Surgical Procedures	N/A
Completed	`NCT02984098` - 40% Orally Administered Dextrose Gel is More Effective Than 25% Dextrose	Phase 4
Completed	`NCT02380989` - Integrative Ayurveda Healing Relieves Minor Sports Injury Pain	Phase 2
Completed	`NCT03107338` - Preventive Treatment of Pain After Dental Implant Surgery	Phase 4
Completed	`NCT02489630` - Low Dose Ketamine as an Adjunct to Opiates for Acute Pain in the Emergency Department	Phase 4
Completed	`NCT02817477` - Intranasal Ketamine for Acute Traumatic Pain	Phase 4

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Effect of Low Power Laser in Tooth Pain Modulation Caused by Irreversible Inflammation

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms