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Fentanyl OR Esketamine for Traumatic PAIN (FORE-PAIN) Trial — FORE-PAIN  

Analgesia Clinical Trial

Official title:
Fentanyl OR Esketamine for Traumatic PAIN (FORE-PAIN) Trial

Clinical Trial Summary

Fentanyl and esketamine are both standard of care for treatment of acute severe traumatic pain in the prehospital setting in the Netherlands. However, it is not known whether they are equally effective and safe. It is also not known whether intranasal (IN) administration of fentanyl or esketamine is equally effective and safe as intravenous (IV) administration. The FORE-PAIN trial is a double-blind multi-arm randomized non-inferiority trial comparing Fentanyl IN, esketamine IV and esketamine IN (intervention arms) to fentanyl IV (comparator arm) for prehospital management of traumatic pain. The investigators hypothesize that all intervention arms provide analgesia that is non-inferior to the comparator arm, and that all study arms are equally safe.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06051227
Study type Interventional
Source Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Contact Robert P Weenink, PhD
Phone +31 205669111
Email forepain@amsterdamumc.nl
Status Recruiting
Phase Phase 3
Start date January 11, 2024
Completion date March 2025
View Details
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