Mesenchymal Stem Cell Transplantation for Acute-on-chronic Liver Failure

Status Recruiting

Clinical Trial Summary

Mesenchymal stem cells (MSC) has been reported to improved outcomes of acute-on-chronic liver failure(ACLF). More randomization controlled studies are needed to confirm the effect of MSC treatment for ACLF. This study aimed to investigate the efficacy of mesenchymal stem cells in ACLF patients. This study is an double-blind multicenter randomized and placebo-controlled study. Patients with with ACLF will be randomly assigned to receive MSC treatment (experimental) or standard medical treatment (control). Three times of MSC infusion (0.1-1x10E6cells/kg body weight) via peripheral vein will be given to the experimental group (once per week). The primary outcome is 12 week mortality. Secondary outcomes are clinical remission rate and changes of liver function indices and liver function scores.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03668171
Study type	Interventional
Source	Xijing Hospital of Digestive Diseases
Contact	Ying Han, MD
Phone	862984771539
Email	guochc@fmmu.edu.cn
Status	Recruiting
Phase	N/A
Start date	December 10, 2017
Completion date	December 31, 2020

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See also
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