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Clinical Trial Summary

Acute-on-chronic liver failure (ACLF) is a syndrome that has recently been recognized as encompassing acute deterioration of liver function in patients with pre-existing chronic liver disease. It is associated with multi-organ failure and a high risk of short-term mortality. Thrombocytopenia is common in ACLF. In addition, the function of platelet is also compromised according to our previous data. The aim of this study is to explore whether platelet transfusion could reduce the short-term mortality rate of HBV-related ACLF. This is a single center, open labeled randomized controlled study. There are two arms. Subjects who is assigned to platelet transfusion group will receive both platelet transfusion (9 times/4 weeks, 1 unit each time) and standard medical treatment. While those in standard medical treatment group will receive standard medical treatment only. The major endpoint is 28-day transplant-free mortality rate.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03713489
Study type Interventional
Source Nanfang Hospital of Southern Medical University
Contact Jinjun Chen
Phone +8618588531001
Email chjj@smu.edu.cn
Status Recruiting
Phase N/A
Start date October 1, 2018
Completion date September 30, 2019

See also
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