Acute-On-Chronic Liver Failure in Zagazig University Hospitals

Acute-On-Chronic Liver Failure Clinical Trial

— ACLF  

Official title:

ACLF in Zagazig University Hospitals

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03184636
• Other study ID #: acute on chronic liver failure
• Status: Completed
• Start date: July 1, 2017
• Est. completion date: August 11, 2018

Study information

• Verified date: August 2018
• Source: Zagazig University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Rationale:

To identify the prevalence of Acute-on-chronic liver failure in Zagazig University Hospitals.

The question of the research:

How much the prevalence of Acute-on-chronic Liver Failure in Zagazig University Hospitals?

The aim of the work:

The aim of the study is to identify the presence of Acute-on-chronic Liver Failure in Zagazig University Hospitals

Objectives:

To estimate the prevalence of Acute-on-chronic Liver Failure in Zagazig University Hospitals.

Subjects and Methods:

I . Technical Design:

• Site of the study: Gastroenterology and Hepatology Unit- Zagazig University Hospitals

• Sample size: ''all patients admitted to Gastroenterology and Hepatology Unit with the criteria of ACLF according to EASL-AASLD from June 2017 to December 2017 were included in this study''.

II . OPERATIONAL DESIGN:

• Type of the study: a prospective study.

• Full medical history - taking.

• Full clinical examination.

• Laboratory investigations including Routine laboratory investigation " CBC, Liver functions test, kidney functions test and prothrombin time "

III. Administrative Design:

• Approvals obtained for performing the study from the official or governmental department.

• An ethical committee from the faculty of medicine and patients included in the study.

Results:

Collected data will be presented in tables and suitable graphs and analyzed according to standard statistical methods

Recruitment information / eligibility

• Status: Completed
• Enrollment: 300
• Est. completion date: August 11, 2018
• Est. primary completion date: August 11, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• all patients admitted to Gastroenterology and Hepatology Unit with the criteria of ACLF according to EASL-AASLD will be included in this study.

Exclusion Criteria:

• no any exclusion criteria

Related Conditions & MeSH terms

• Acute-On-Chronic Liver Failure
• End Stage Liver Disease
• Liver Failure

Locations

Country	Name	City	State
Egypt	Salem Mohamed	Zagazig	Sharqia

Sponsors (1)

Lead Sponsor	Collaborator
Zagazig University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	improvement of the patients score according to SOFA score (AASLD and EASL guidelines)	follow up of participants until the patients recover	24 weeks from first recruiting
Secondary	death of the patient	due to the severity of acute on chronic failure, the death of patients is expected	24 weeks from first recruiting