The Efficacy of Allogeneic Hematopoietic Stem Cell Transplantation in Newly Diagnosed High-relapse-risk CEBPA Mutant Acute Myeloid Leukemia

Acute Myeloid Leukemia Clinical Trial

Official title:

The Efficacy of Allogeneic Hematopoietic Stem Cell Transplantation in Newly Diagnosed High-relapse-risk CEBPA Mutant Acute Myeloid Leukemia

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06458257
• Other study ID #: CEBPA-AML01
• Status: Not yet recruiting
• Start date: June 2024
• Est. completion date: December 2028

Study information

• Verified date: June 2024
• Source: Ruijin Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

For newly diagnosed high-relapse-risk CEBPA mutant acute myeloid leukemia patients, we aim to perform allogeneic hematopoietic stem cell transplantation after patients finished one cycle of induction and two cycles of consolidation. To access whether the therapeutic regimen is effective for high-relapse-risk CEBPA mutant acute myeloid leukemia, the disease-free-survival (DFS), overall survival (OS), non-relapse-mortality of patients is evaluated.

Description:

High-relapse-risk definition:

Participants with non-bZIP in-frame mutations, WT1 mutated status or CD7 negative status are considered of high-relapse-risk; The positive threshold for flow cytometry MRD was 0.0001%; The MRD threshold of molecular biology is the lowest value of the detection protocol of the center.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 50
• Est. completion date: December 2028
• Est. primary completion date: December 2026
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

1. Patients with confirmed CEBPA mutant AML. Diagnostic criteria include the presence of CEBPA mutant gene detected at the molecular level;

2. Patients with high-risk molecular markers or gene mutations, or complex karyotypes for disease recurrence, or flow cytometry/gene MRD positivity after two chemotherapy treatments; high-risk molecular markers or gene mutations include: CD7 positive, WT1 mutation, non-bzip-inframe CEBPA mutation; The positive threshold for flow cytometry MRD was 0.0001%; The MRD threshold of molecular biology is the lowest value of the detection protocol of the center.

3. Medical history and diagnosis of MICM, exclusion of MDS, transformation and treatment-related AML;

4. Age 18-65 years old (18 years old =Age< 65 years old);

5. Liver and kidney function: blood bilirubin = 35 µmol/L, AST/ALT below 2 times the upper limit of normal, serum creatinine = 150 µmol/L;

6. Normal cardiac function (EF=50%, New York Cardiac Function Classification NYHA I/II);

7. Physical condition score 0-2 (ECOG score);

8. For patients with peripheral blood leukocytes < 50*109/L at the initial onset, no chemotherapy has been given except for hydroxyurea before the start of induction therapy;

9. For patients with peripheral blood leukocytes = 50*109/L at the initial onset, cytarabine and hydroxyurea are allowed to be treated before the start of induction therapy;

10. Non-pregnant and lactating women;

11. For all women of childbearing age, a pregnancy test must be performed to measure hCG to rule out pregnancy;

12. Obtain informed consent signed by the patient or family member.

Exclusion Criteria:

1. MDS-converted AML, treatment-related AML; mixed cell leukemia; AML patients with central nervous system infiltrates and extramedullary lesions at the time of onset;

2. Relapse patients;

3. Allergies or contraindications to any of the drugs involved in the protocol;

4. Liver and kidney function are obviously abnormal, exceeding the enrollment criteria;

5. Cardiac disease: including echocardiogram EF <50%, cardiac insufficiency (New York cardiac function classification NYHA: III/IV), pericardial effusion (CTCAE score >2) within six months after acute myocardial infarction, ECG QTc >470ms;

6. Lung diseases: pulmonary edema, pleural effusion (CTCAE score >2);

7. Suffering from malignant tumors of other organs at the same time;

8. Active patients with HAV, HBV, HCV and tuberculosis, HIV-positive patients;

9. Concomitant other hematologic diseases (including coagulation abnormalities unrelated to leukemia);

10. Inability to understand or follow the study protocol;

11. Those who participate in other clinical studies at the same time; Presence of any other condition that would preclude the conduct of the study

Related Conditions & MeSH terms

• Acute Myeloid Leukemia
• Leukemia
• Leukemia, Myeloid
• Leukemia, Myeloid, Acute
• Recurrence

Intervention

Procedure:
• Allogeneic Hematopoietic Stem Cell Transplantation
Allogeneic Hematopoietic Stem Cell Transplantation

Drug:
• Chemotherapy
Chemotherapy

Locations

Country	Name	City	State
China	Ruijin Hospital Affiliated to Shanghai Jiaotong University School Of Medicine	Shanghai	Shanghai

Sponsors (1)

Lead Sponsor	Collaborator
Ruijin Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	disease-free-survival	disease-free-survival	from data of AML diagnosis until the data of AML relapse, assessed up to 3 years
Primary	The relation of CEBPA Mutant AML genetics subgroup with MRD negativity rate after chemotherapy and DFS after transplantation	The relation of CEBPA Mutant AML genetics subgroup with MRD negativity rate after chemotherapy and DFS after transplantation	from enrollment to study completion, a maximum of 3 years
Secondary	non-relapse-mortality	non-relapse-mortality	from enrollment to study completion, a maximum of 3 years
Secondary	overall survival	overall survival	from enrollment to study completion, a maximum of 3 years
Secondary	adverse events	adverse events	from enrollment to study completion, a maximum of 3 years