| Eligibility |
Inclusion Criteria:
Patients must meet all of the following inclusion criteria to be eligible for enrollment
into the study:
1. Documented diagnosis of MDS, according to World Health Organization (WHO)
classification (Appendix 1) and assessed as higher risk MDS, prior to first line
hypomethylating agents (HMA) treatment, according to the Revised International
Prognostic Scoring System (IPSS-R) (IPSS-R overall score = 4.5) Or Diagnosed AML
according to the 2016 revision to the WHO classification of myeloid neoplasms and
acute leukemia: =20% blasts in peripheral blood or bone marrow
2. Adult =18 years of age
3. Failure/relapse following prior first-line AML or MDS treatment, defined as:
1. For MDS:
- Relapse after initial complete or partial response or stable disease with
hematologic improvement (HI), according to International Working Group (IWG)
2006 criteria following treatment with azacitidine or decitabine Or
- Failure to achieve complete or partial response or stable disease with
hematologic improvement (HI) according to International Working Group (IWG)
2006 criteria after at least 4 cycles of azacitidine or decitabine, all
within the last 1 year Or iii. MDS progression while on azacitidine or
decitabine treatment irrespective of the number of cycles the patient has
received
2. For AML:
- Relapse after initial CR/CRi/CRh following treatment with: azacitidine,
decitabine, Low-Dose Ara-C (cytarabine) [LDAC] (20 mg/m2/d), venetoclax+HMA,
or venetoclax+LDAC Or
- Failure to achieve CR, CRh or CRi following at least 4 cycles of azacitidine
or decitabine or 2 cycles of venetoclax+HMA or venetoclax+LDAC within the
last 1 year.
Or
- AML progression while on azacitidine, decitabine, LDAC, venetoclax+HMA,
venetoclax+LDAC, irrespective of the number of cycles the patient has received.
4. The participant is not able to receive an allogeneic bone marrow transplantation (BMT)
at the time of study enrolment (BMT may be an option once the patient completed the
study).
5. Not eligible for intensive chemotherapy;
1. Age =75 years Or
2. Age =18 years with at least one of the following comorbidities:
I. Significant heart or lung comorbidities, as reflected by at least one of the
following:
- Left ventricular ejection fraction (LVEF) =50%
- Lung diffusing capacity for carbon monoxide (DLCO) =65% of expected
- Forced expiratory volume in 1 second (FEV1) =65% of expected II. Other
comorbidity that the Investigator judges as incompatible with intensive
chemotherapy, which must be documented
6. Creatinine clearance (estimated by the Modification of Diet in Renal Disease (MDRD)
equation or measured by 24 hours urine collection) =45 mL/min
7. Liver enzymes (aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT)
=2.5 times the upper limits of normal (ULN), unless attributed to leukemia (in AML
patients)
8. Total bilirubin =3 XULN unless due to Gilbert disease
9. Eastern Cooperative Oncology Group (ECOG) performance status = 2
10. Women of reproductive potential must have a negative serum pregnancy test within 48
hours prior to the first day of any BST-236 treatment course
11. Women of reproductive potential must use two forms of effective birth control methods
starting from at least 1 month prior to BST-236 first dose and until 6 months
following the last BST-236 administration day (acceptable methods of birth control in
this study include: surgical sterilization, intrauterine devices, intrauterine
hormone-releasing system, long-acting injectable contraceptives, or vasectomized
partner (provided that partner is the sole sexual partner)
12. Male subjects must agree to refrain from unprotected sex unless vasectomized and from
sperm donation from initial study drug administration until 6 months following the
last dose of study drug
13. Subject must voluntarily sign and date an informed consent, approved by an Independent
Ethics Committee (IEC)/Institutional Review Board (IRB), prior to the initiation of
any screening or study-specific procedures
14. Patient must be able to adhere to the study visit schedule and other protocol
requirements
Exclusion Criteria:
Patients with any one of the exclusion criteria listed below are not eligible for the
study:
1. MDS or AML evolving from a pre-existing myeloproliferative neoplasm (MPN)
2. MDS/MPN including chronic myelomonocytic leukemia (CMML), atypical chronic myeloid
leukemia (CML), juvenile myelomonocytic leukemia (JMML) and unclassifiable MDS/MPN
3. Acute promyelocytic leukemia
4. Previous treatment for AML or MDS with drugs other than HMA or LDAC or combinations of
venetoclax with either HMA or LDAC
5. Previous allogeneic hematopoietic stem cell transplantation (HSCT) or solid organ
transplantation
6. Participation in a previous clinical trial involving use of an investigational drug
within 30 days or at least 5 half-lives of tested drug (whichever is shorter) of study
day 1
7. Peripheral White Blood Cell (WBC) count >30,000/L in the 48 hours prior to first
BST-236 dose administration. Hydroxyurea administration or leukapheresis is permitted
to meet this criterion
8. Administration of HMA, LDAC, or venetoclax within 14 days prior to Study Day 1
9. Previous treatment with cytarabine at a dose higher than 20 mg/ m2/d
10. Uncontrolled systemic fungal, bacterial, or viral infection (defined as ongoing
signs/symptoms related to the infection without improvement despite appropriate
antibiotics or other treatment)
11. Any medical or surgical condition, presence of laboratory abnormalities or psychiatric
illness that may preclude safe and complete study participation based on the
Investigator's judgment
12. Diagnosis of malignant disease (other than AML) within the previous 12 months
(excluding basal cell carcinoma of the skin without complications, "in-situ"
carcinoma, or other local malignancy excised or irradiated with a high probability of
cure and not treated with systemic or topical chemotherapy)
13. Surgical procedure, excluding central venous catheter placement or other minor
procedures (e.g. skin biopsy) in the 14 days prior to first BST-236 dose
administration
14. History of allergic reactions attributed to compounds of similar chemical composition
as BST-236 and/or cytarabine
15. Life expectancy shorter than 3 months attributed to any known medical condition other
than AML/MDS
16. Known infection with Hepatitis B Virus (HBV) Hepatitis C Virus (HCV) or Human
Immunodeficiency Virus (HIV)
17. In 12 leads ECG, corrected QT interval (QTc)>480msec or history of QT prolongation or
Torsades de pointes
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