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NCT04169022 Clinical Trial

AML Cell Immunotherapy Using Chimeric Antigen Receptor T-cells

Acute Myeloid Leukemia Clinical Trial

— CAR-LAM  

Official title:
Targeting Interleukin 1 Receptor Accessory Protein (IL1RAP) Expressing Acute Myeloid Leukemic (AML) Cells by Chimeric Antigen Receptor (CAR) Engineered T-cells

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04169022
Other study ID # P/2018/402
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date July 10, 2019
Est. completion date October 2, 2023

Study information
Verified date February 2024
Source Centre Hospitalier Universitaire de Besancon
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

AML is one of the most aggressive forms of leukemia, where bone marrow transplantation remains the gold standard treatment, with its known associated toxicities and related mortality. Despite progress in the treatment of leukemic malignancies, especially the emergence of targeted- and immuno-therapies arising from biological genomic knowledge, there remains a need to provide additional strategies for refractory/relapsing (R/R) patients Aim of this study is to collect biological samples of AML patients in order to validate our Chimeric Antigen Receptor T-cells immunotherapy approach

Recruitment information / eligibility
Status Completed
Enrollment 86
Est. completion date October 2, 2023
Est. primary completion date October 2, 2023
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria: - AML patients adults and pediatrics Exclusion Criteria: - AML3

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Sample collection
Sample collection blood and/or bone marrow

Locations
Country Name City State
France CHU Besançon Besançon

Sponsors (3)
Lead Sponsor Collaborator
Centre Hospitalier Universitaire de Besancon Centre Hospitalier Universitaire Dijon, Etablissement Français du Sang

Country where clinical trial is conducted

France, 

Outcome
Type Measure Description Time frame Safety issue
Primary IL1RAP protein expression Cytometry analysis 2 years
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