Acute Myeloid Leukemia Clinical Trial
— LAM-PTK7Official title:
Role of PTK-7 in Acute Myeloid Leukemias: Impact of PTK7 Serum Marker and ex Vivo Studies to Decipher the Role of PTK7
The pseudo tyrosine kinase receptor 7 (PTK7) is an orphan tyrosine kinase receptor assigned
to the planar cell polarity pathway. PTK7 is expressed in normal myeloid progenitors and
CD34(+) CD38(-) bone marrow cells in humans. It is also expressed in acute myeloid leukemia
(AML) and is mostly assigned to granulocytic lineage differentiation. In AML, PTK7 seems to
convey promigratory and antiapoptotic signals into the cell and represents an independent
prognosis factor of survival in patients treated with induction chemotherapy. This study
aims at:
- evaluating the impact of PTK7 expression on primary AML cells ex vivo
- evaluating the diagnostic and prognostic value of a soluble form of PTK7
Status | Completed |
Enrollment | 10 |
Est. completion date | |
Est. primary completion date | April 2015 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Age> 18 years - AML at diagnosis, not previously treated - Treatment by induction chemotherapy - Signed informed consent - Affiliation to the French social security system Exclusion Criteria: - pregnant woman(or of childbearing potential) or breastfeeding woman - emergency - patients deprived of liberty or placed under the authority of a tutor |
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
Country | Name | City | State |
---|---|---|---|
France | Institut Paoli Calmettes | Marseille | Bouches du Rhone |
Lead Sponsor | Collaborator |
---|---|
Institut Paoli-Calmettes |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Evaluation PTK7+ and PTK7- AML cells hematopoietic homing abilities in xenografted mice by in vivo bioluminescence imaging | 1 day | No | |
Primary | Soluble PTK7 measurement in the serum | 12 years | No |
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