Acute Myeloid Leukemia Clinical Trial
Official title:
Role of PTK-7 in Acute Myeloid Leukemias: Impact of PTK7 Serum Marker and ex Vivo Studies to Decipher the Role of PTK7
The pseudo tyrosine kinase receptor 7 (PTK7) is an orphan tyrosine kinase receptor assigned
to the planar cell polarity pathway. PTK7 is expressed in normal myeloid progenitors and
CD34(+) CD38(-) bone marrow cells in humans. It is also expressed in acute myeloid leukemia
(AML) and is mostly assigned to granulocytic lineage differentiation. In AML, PTK7 seems to
convey promigratory and antiapoptotic signals into the cell and represents an independent
prognosis factor of survival in patients treated with induction chemotherapy. This study
aims at:
- evaluating the impact of PTK7 expression on primary AML cells ex vivo
- evaluating the diagnostic and prognostic value of a soluble form of PTK7
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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