Acute Myeloid Leukemia Clinical Trial
Official title:
Bone Marrow and Peripheral Blood (PB) Samples From Patients With Leukemia and PB From Their BM Donors (BMD) to Identify Leukemia-Specific Antigens (LSA) and Graft Versus Host Disease Antigens (GVHDA) for Use in Cellular Immunotherapy
The purpose of this project is to develop a process to identify highly personalized antigens that are uniquely expressed by the patient's own leukemia cells that can be used for cellular immune therapy.
It is well known that tumor cells and leukemia cells express different surface structures
(called antigens) that can serve as targets for cancer cell destruction by the immune system.
Effective immune therapies are characterized by high specificity and low toxicity. One of the
major obstacles impeding the use of these therapies as standard of care is the identification
of good target antigens. In acute myeloid leukemia (AML) there is major patient to patient
variation in leukemia antigens, so there is no universal AML cell target. Rather, each
patient has a unique array of potential cell targets. Thanks to the rapid progress of new
DNA/RNA sequencing technologies, the identification of these unique, patient-specific
leukemia cell antigen-targets is now possible.
The purpose of this project is to develop a process to identify highly personalized antigens
that are uniquely expressed by the patient's own leukemia cells that can be used for cellular
immune therapy.
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