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Clinical Trial Summary

To evaluate the safety and efficacy of anti-Siglec-6 CAR-T cells in the treatment of relapsed and refractory acute myeloid leukemia.


Clinical Trial Description

Sialic acid-binding immunoglobulin-like lectins (Siglec) are a class of classical immunoglobulin-like lectins. Studies have shown that Siglec-6 is commonly expressed in AML but not detected on normal hematopoietic stem and progenitor cells (HSC/P). In vitro experiments revealed that anti-Siglec-6 CAR-T cell treatment did not affect the viability or lineage differentiation in colony-forming assays. These data suggest that anti-SigLlec-6 is an ideal target with great potential for treating acute myeloid leukemia. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05488132
Study type Interventional
Source Xuzhou Medical University
Contact Kailin Xu, M.D., Ph.D.
Phone 15162166166
Email lihmd@163.com
Status Recruiting
Phase Phase 1/Phase 2
Start date April 1, 2022
Completion date March 31, 2025

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