Acute Myeloid Leukemia, in Relapse Clinical Trial
Official title:
Analysis of T Cell Metabolism and Immune Phenotype in Relapsed Acute Myeloid Leukemia Patients Receiving Donor Lymphocyte Infusions and Bicanorm (Sodium Bicarbonate)
In this study, the outcomes of relapsed AML patients receiving DLIs and Bicanorm (Sodium bicarbonate) were analyzed including T cell metabolism and immune phenotype.
Acute myeloid leukemia (AML) patients suffering from relapse after allogeneic hematopoietic
cell transplantation (allo-HCT) have a poor survival outcome. Donor lymphocyte infusions
(DLIs) to induce graft-versus-leukemia (GvL) effects have a limited survival benefit.
Extensive preclinical studies have shown a beneficial effect of sodium bicarbonate on
metabolic fitness of leukemia-reactive T cells in GvL AML models. Therefore, the
investigators aimed to investigate a potential benefit of Bicanorm (Sodium bicarbonate)
treatment accompanying DLIs in relapsed AML patients. The investigators determined the
metabolic and immune phenotype of T cells isolated from patients receiving DLIs before and
after Bicanorm (Sodium bicarbonate) treatment.
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