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Clinical Trial Summary

A phase I, open-label clinical study to evaluate the safety, tolerability, and efficacy of LCAR-AIO, a triple-targeted cell preparation targeting CD19/CD20/CD22, in patients with relapsed/refractory B-cell acute lymphocytic leukemia


Clinical Trial Description

This is an open-label, dose escalation/expansion study to assess the safety, tolerability, and efficacy of LCAR-AIO in patients ≥ 18 years of age with relapsed or refractory B-cell acute lymphocytic leukemia. Patients who meet the eligibility criteria will receive a single dose of LCAR-AIO infusion. The study will include the following sequential phases: screening, pre-treatment (cell product preparation; lymphodepleting chemotherapy), treatment and follow up. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05292898
Study type Interventional
Source Institute of Hematology & Blood Diseases Hospital, China
Contact
Status Active, not recruiting
Phase Phase 1
Start date March 14, 2022
Completion date July 2026

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