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Clinical Trial Summary

In this trial, the investigators will begin to explore the possibility that, as in mice, janus kinase inhibitor 1 (JAK1) inhibition with haploidentical-hematopoietic cell transplantation (HCT) may mitigate graft-versus-host-disease (GVHD) and cytokine release syndrome (CRS) while retaining Graft-versus-Leukemia (GVL) and improving engraftment. The purpose of this pilot study is to determine the safety of itacitinib with haplo-hematopoietic cell transplantation (HCT) measured by the effect on engraftment and grade III-IV GVHD.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03755414
Study type Interventional
Source Washington University School of Medicine
Contact
Status Active, not recruiting
Phase Phase 1
Start date September 4, 2019
Completion date September 5, 2024

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