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Clinical Trial Summary

A Study of Metabolically Armed CD19 CAR-T Cells Therapy for Patients With Relapsed and/or Refractory CD19-positive B cell Hematological Malignancies


Clinical Trial Description

This is a single arm, open-label study. This study is indicated for relapsed or refractory CD19-positive B cell Hematological Malignancies. 1. Main research objectives: To evaluate the safety and efficacy of metabolically armed CD19 CAR-T Cells in the treatment of r/r CD19-positive B cell Hematological Malignancies 2. Secondary research objectives: 1. To evaluate the pharmacokinetic (PK) and pharmacodynamics(PD) characteristics of metabolically armed CD19 CAR-T Cells after infusion. 2. To evaluate tumor remission after infusion of metabolically armed CD19 CAR-T Cells. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06393335
Study type Interventional
Source The Children's Hospital of Zhejiang University School of Medicine
Contact Xiaojun Xu, PhD
Phone 86- 13858067554
Email xuxiaojun@zju.edu.cn
Status Recruiting
Phase Early Phase 1
Start date May 15, 2024
Completion date March 15, 2026

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