Intrabronchial Airway Pressures in Intubated Patients During Bronchoscopy

Status Completed

Clinical Trial Summary

The purpose of this study is to examine changes in ventilation and airway pressures during conventional bronchoscopy of intubated patients.

Clinical Trial Description

Mechanically ventilated patients often need bronchoscopy as a diagnostic procedure or for visually directed elimination of secretions. Partial endotracheal tube occlusion by the bronchoscope increases airflow resistance. Inhibition of inspiratory flow may be compensated for by augmented inspiratory pressure. Reduced expiratory flow however, cannot be compensated for by most ventilators and could lead to higher airway - and intrathoracic pressures that are not detected by pressure transducers in the ventilator tubing. In this study we compare changes in ventilation, airway pressures, ventilator pressures and blood gases during bronchoscopy of intubated patients in both volume controlled and pressure controlled ventilation. Our hypothesis are that 1) increased resistance in the tube during bronchoscopy leads to high intrabronchial airway pressures when the ventilator is in volume controlled mode, and 2) when the ventilator is in pressure controlled mode, increased resistance in the tube during bronchoscopy leads to reduced Tidal Volume and moderately increased paCO2. ;

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

Acute Lung Injury
Acute Lung Injury (ALI)
Acute Respiratory Distress Syndrome
Lung Injury
Respiratory Distress Syndrome, Adult
Respiratory Distress Syndrome, Newborn

Clinical Trial Details

NCT number	NCT01078831
Study type	Observational
Source	Oslo University Hospital
Contact
Status	Completed
Phase	N/A
Start date	March 2002
Completion date	April 2010

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