Prevention of Cisplatin-induced Nephrotoxicity

Status Not yet recruiting

Clinical Trial Summary

The research design is a prospective, randomized, controlled clinical trial in children to study effect of aminophylline in preserving renal function in oncologic patient received cisplatin either combined with other CMT or used alone. The participants in both groups will receive standard protocol pre-cisplatin infusion which include hydration with 5%DNSS/2 with KCL and MgSO4 IV infusion. In the treatment group, the participants will receive aminophylline infusion in the first 24 hours along with cisplatin, followed by oral aminophylline oral three times daily orally for 4 consecutive days post cisplatin. The aminophylline serum level will be maintained at the therapeutic range 10-20 mg. The side effect of aminophylline including nausea, vomiting and ECG will be monitored. The collected data including urine volume, GFR (estimated by cystatin C-creatinine based equation and by radiopharmaceutical-Tc DTPA), and renal tubular biomarker (urine B2 macroglobulin and urine NGAL) will be collected at baseline before receiving cisplatin, 24 hours and 5 days post cisplatin.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Acute Kidney Injury

Clinical Trial Details

NCT number	NCT06196853
Study type	Interventional
Source	Mahidol University
Contact	Anirut Pattaragarn, MD
Phone	66816651020
Email	apattaragarn@yahoo.com
Status	Not yet recruiting
Phase	Phase 2/Phase 3
Start date	April 1, 2024
Completion date	September 30, 2025

View Details

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