Homburg Renal Evaluation Study on the Clinical Utility of Early AKI Diagnosis — RESCUE-AKI  

Acute Kidney Injury Clinical Trial

Official title: Homburg Renal Evaluation Study on the Clinical Utility of Early AKI Diagnosis

Status Recruiting

Clinical Trial Summary

Critically ill patients are at risk of developing a sudden decrease of kidney function which may be detected by a decrease in urine output or is diagnosed on the basis of blood tests for substances normally eliminated by the kidney, primarily creatinine.

Because it takes about 24 hours for the creatinine level to rise, even if both kidneys have ceased to function, better markers are needed.

This trial is investigating if the marker urinary dickkopf-3 (uDKK3) allows an early prediction of a sudden decrease of kidney function.

Clinical Trial Description

Urinary dickkopf-3 (uDKK3), a stress-induced renal tubular epithelium-derived glycoprotein, has been identified as a biomarker predicting persistent kidney dysfunction.

In this prospective observational trial in patients at high risk of developing acute kidney injury we will assess whether urinary dickkopf-3 serves as a predictor of acute kidney injury.

Patients of the intensive care units of Saarland University Hospital will be surveyed for up to two years after their admission to the intensive care unit.

The progression of the estimated Glomerular Filtration Rate and uDKK3 will be monitored. ;

Related Conditions & MeSH terms

• Acute Kidney Injury

• NCT number: NCT06180551
• Study type: Observational [Patient Registry]
• Source: Universität des Saarlandes
• Contact: Stefan Neuhaus, MD
• Phone: +4968411615041
• Email: stefan.neuhaus@uks.eu
• Status: Recruiting
• Start date: December 1, 2023
• Completion date: June 2027