Acute Kidney Injury Clinical Trial
Official title:
Correlation Between the Preoperative N-terminal Pro-B-type Natriuretic Peptide and Acute Kidney Injury After Abdominal Surgery: a Single Center Retrospective Cohort Study Based on ERAS Database
NCT number | NCT06145347 |
Other study ID # | KY-20230560 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | July 10, 2023 |
Est. completion date | March 31, 2024 |
Accurate preoperative AKI risk prediction is of great significance for improving patient outcomes. The use of preoperative NT-proBNP can provide a more precise assessment of the body's fluid load status, guide intraoperative and postoperative fluid management, and thus reduce fluid related postoperative complications. Given the potential association between ERAS and increased postoperative AKI, we hypothesize that preoperative NT-proBNP may be associated with the development of postoperative AKI in ERAS, and can improve the prediction of AKI beyond traditional clinical risk factors. This study aims to validate this hypothesis and provide evidence for using NT-proBNP to assess AKI risk before non cardiac surgery. Improve the predictive ability of clinical predictive models and optimize ERAS protocols to prevent postoperative AKI.
Status | Recruiting |
Enrollment | 633 |
Est. completion date | March 31, 2024 |
Est. primary completion date | February 28, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: 1. =18 years 2. undergoing elective surgery 3. Have a history of NT-proBNP and creatinine testing within 7 days before surgery Exclusion Criteria: 1. Patients undergoing chronic peritoneal or hemodialysis treatment; patients who have undergone kidney transplantation; preoperative serum creatinine levels>4.5mg/dL (400 µ Mol/L) or end-stage renal disease patient (defined as glomerular filtration rate<15ml • min-1 • 1.73m-2) 2. Organ transplantation surgery 3. Pregnant patients 4. Surgical duration<1 hour |
Country | Name | City | State |
---|---|---|---|
China | Xijing Hospital | Xi'an | Shaanxi |
Lead Sponsor | Collaborator |
---|---|
Xijing Hospital |
China,
Ojo B, Campbell CH. Perioperative acute kidney injury: impact and recent update. Curr Opin Anaesthesiol. 2022 Apr 1;35(2):215-223. doi: 10.1097/ACO.0000000000001104. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Incidence of AKI assessed by KDIGO 2012 (Kidney Disease: Improving Global Outcomes) | Postoperative incidence of AKI, serum creatinine increases= 0.3mg/dL (= 26.5 µ Mol/L) within 48 hours, or the serum creatinine increases to 1.5 times or more of the baseline value within 7 days. | 1 week | |
Secondary | AKI grading assessed by KDIGO 2012 (Kidney Disease: Improving Global Outcomes) | Postoperative AKI grading, KDIGO stage 1 AKI is defined as an increase in serum creatinine of 1.5-1.9 times the baseline value or an increase of = 0.3mg/dL (26.5 µ Mol/L); KDIGO stage 2 AKI: serum creatinine increased to 2-2.9 times the baseline value; KDIGO stage 3 AKI is defined as an increase in blood creatinine to a 3-fold baseline value or 4mg/dL (353.6 µ Mol/L or above, or initiate renal replacement therapy. | 1 week | |
Secondary | Morbidity | Total postoperative complication | 4 week |
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