Lithium Clearance in Patients With High Risk of Acute Kidney Injury

Status Completed

Clinical Trial Summary

Renal lithium clearance is hypothesized to be a useful indicator of renal tubular function. In this study lithium clearance will be monitored in patients with sepsis associated acute kidney injury and in healthy controls.

Clinical Trial Description

Lithium is almost completely reabsorbed in the proximal tubule in parallel with sodium and water. What is not reabsorbed here is assumed to be fully excreted in urine, giving a reasonably accurate measurement of sodium reabsorption in the proximal tubule. Endogenous lithium clearance will be measured by inductively coupled plasma mass spectrometry (ICP-MS). The Gomez equations will be applied to calculate efferent arteriolar resistance, afferent arteriolar resistance, glomerular hydrostatic pressure, glomerular filtration pressure, and glomerular oncotic pressure. N-acetyl-β-D glucosaminidase (NAG) and NGAL, markers of tubular injury, will be measured by a spectrophotometric method using a commercially available kit. Routine blood and urine analyses will be performed at the Diagnostic Clinic Laboratory, University Hospital of North Norway, Tromsø. ;

Study Design

Related Conditions & MeSH terms

Acute Kidney Injury

Clinical Trial Details

NCT number	NCT05648435
Study type	Observational [Patient Registry]
Source	University Hospital of North Norway
Contact
Status	Completed
Phase
Start date	December 7, 2022
Completion date	January 31, 2023

View Details

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