Acute Kidney Injury Clinical Trial
Official title:
Long Term Renal Function After CRRT in the Paediatric Intensive Care Unit, a Follow-up Study.
Verified date | April 2024 |
Source | Region Stockholm |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational [Patient Registry] |
In this study the investigators will evaluate the long-term renal function in children treated with continuous renal replacement therapy (CRRT) due to acute kidney injury (AKI) and multiple organ failure (MOF) in the pediatric intensive care unit (PICU). These children are not always referred for nephrology follow up after their ICU stay and it is unclear to what extent the patients suffer from chronic renal disease. The primary aim is to establish the frequency of chronic kidney disease (CKD) in children treated with CRRT due to AKI. Secondary outcomes will include mortality, frequency of end stage-renal disease (ESRD) and need for hemodialysis and/or renal transplantation.
Status | Enrolling by invitation |
Enrollment | 300 |
Est. completion date | December 2024 |
Est. primary completion date | June 2024 |
Accepts healthy volunteers | |
Gender | All |
Age group | N/A to 18 Years |
Eligibility | Inclusion Criteria: - Age newborn to 18 when admitted to ICU. CRRT treatment 2008-2021 due to AKI stage = stage 1 (according to KDIGO) and/or = 2 organ failures Exclusion Criteria: - CRRT due to metabolic and/or endocrinologic comorbidity. - Chronic renal failure before CRRT. - Previous renal transplantation. Prospective part: - Not a resident of Stockholm County and no planned follow up at Karolinska University Hospital. Retrospective part: - Patient referred to Karolinska University Hospital from a hospital outside Sweden. |
Country | Name | City | State |
---|---|---|---|
Sweden | Pediatric Perioperative Medicine and Intensive Care | Stockholm |
Lead Sponsor | Collaborator |
---|---|
Region Stockholm |
Sweden,
Almarza S, Bialobrzeska K, Casellas MM, Santiago MJ, Lopez-Herce J, Toledo B, Carrillo A. [Long-term outcomes of children treated with continuous renal replacement therapy]. An Pediatr (Barc). 2015 Dec;83(6):404-9. doi: 10.1016/j.anpedi.2014.12.018. Epub — View Citation
Andersson A, Norberg A, Broman LM, Martensson J, Flaring U. Fluid balance after continuous renal replacement therapy initiation and outcome in paediatric multiple organ failure. Acta Anaesthesiol Scand. 2019 Sep;63(8):1028-1036. doi: 10.1111/aas.13389. Ep — View Citation
Askenazi DJ, Feig DI, Graham NM, Hui-Stickle S, Goldstein SL. 3-5 year longitudinal follow-up of pediatric patients after acute renal failure. Kidney Int. 2006 Jan;69(1):184-9. doi: 10.1038/sj.ki.5000032. — View Citation
Calderon-Margalit R, Golan E, Twig G, Leiba A, Tzur D, Afek A, Skorecki K, Vivante A. History of Childhood Kidney Disease and Risk of Adult End-Stage Renal Disease. N Engl J Med. 2018 Feb 1;378(5):428-438. doi: 10.1056/NEJMoa1700993. — View Citation
Diane Mok TY, Tseng MH, Chiang MC, Lin JL, Chu SM, Hsu JF, Lien R. Renal replacement therapy in the neonatal intensive care unit. Pediatr Neonatol. 2018 Oct;59(5):474-480. doi: 10.1016/j.pedneo.2017.11.015. Epub 2017 Dec 21. — View Citation
Hayes LW, Oster RA, Tofil NM, Tolwani AJ. Outcomes of critically ill children requiring continuous renal replacement therapy. J Crit Care. 2009 Sep;24(3):394-400. doi: 10.1016/j.jcrc.2008.12.017. Epub 2009 Mar 27. — View Citation
Mammen C, Al Abbas A, Skippen P, Nadel H, Levine D, Collet JP, Matsell DG. Long-term risk of CKD in children surviving episodes of acute kidney injury in the intensive care unit: a prospective cohort study. Am J Kidney Dis. 2012 Apr;59(4):523-30. doi: 10. — View Citation
Morelli S, Ricci Z, Di Chiara L, Stazi GV, Polito A, Vitale V, Giorni C, Iacoella C, Picardo S. Renal replacement therapy in neonates with congenital heart disease. Contrib Nephrol. 2007;156:428-33. doi: 10.1159/000102134. — View Citation
Sutherland SM, Zappitelli M, Alexander SR, Chua AN, Brophy PD, Bunchman TE, Hackbarth R, Somers MJ, Baum M, Symons JM, Flores FX, Benfield M, Askenazi D, Chand D, Fortenberry JD, Mahan JD, McBryde K, Blowey D, Goldstein SL. Fluid overload and mortality in — View Citation
Wu L, Zhang P, Yang Y, Jiang H, He Y, Xu C, Yan H, Guo Q, Luo Q, Chen J. Long-term renal and overall survival of critically ill patients with acute renal injury who received continuous renal replacement therapy. Ren Fail. 2017 Nov;39(1):736-744. doi: 10.1 — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Chronic renal disease (CKD) | Frequency of chronic renal disease (CKD) according to KDIGO definitions at nephrology follow-up. | Up to12 years. | |
Primary | Chronic renal disease (CKD) | Frequency of chronic renal disease according to ICD diagnosis in Swedish National Patient Register. | Up to 12 years | |
Secondary | Hypertension | Frequency of hypertension at nephrology follow-up. | Up to 12 years | |
Secondary | End-stage renal disease | Frequency of end-stage renal disease defined as the need for renal transplantation or dialysis at nephrology follow up. | Up to 12 years | |
Secondary | Hypertension | Frequency of hypertension according to ICD diagnosis in Swedish National Patient Register. | Up to 12 years | |
Secondary | Dialysis Therapy. | Frequency of dialysis therapy according to Swedish National Patient Register. | Up to 12 years | |
Secondary | Renal transplantation | Frequency of renal transplantation according to Swedish National Patient Register | Up to 12 years | |
Secondary | Mortality | PICU mortality | Up to 1 year | |
Secondary | Mortality | All-cause mortality | Up to 12 years |
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