Acute Kidney Injury Clinical Trial
— Amox-CloxaOfficial title:
Incidence of Actue Kidney Injury in Patients Treated With Amoxicillin and Cloxacillin Combination Therapy
| NCT number | NCT05142891 |
| Other study ID # | 8411 |
| Secondary ID | |
| Status | Recruiting |
| Phase | |
| First received | |
| Last updated | |
| Start date | October 15, 2021 |
| Est. completion date | October 30, 2022 |
2015 European Society of Cardiology Guidelines have proposed the combination of Ampicillin and Cloxacillin for initial empirical treatment of infective endocarditis in acute severely ill patients (before pathogen identiļ¬cation). Yet this combination has never been studied in clinical trials. High dose penicillin treatments are associated with a risk of nephrotoxicity. The investigator's primary purpose is to describe patients treated with high dose Amoxicillin and Cloxacillin combination and to evaluate its renal tolerance.
| Status | Recruiting |
| Enrollment | 50 |
| Est. completion date | October 30, 2022 |
| Est. primary completion date | October 2022 |
| Accepts healthy volunteers | |
| Gender | All |
| Age group | 18 Years and older |
| Eligibility | Inclusion criteria: - Adult patient (=18 years old) - Hospitalized at the Strasbourg University Hospital and treated concomitantly with Amoxicillin IV and Cloxacillin IV for =48 hours between January 1, 2016 and December 31, 2020. - Patient not having expressed his opposition, after information, to the reuse of his data for scientific research purposes. Exclusion criteria: - Subject having expressed opposition to participating in the study - Subject under guardianship, curatorship or safeguard of justice |
| Country | Name | City | State |
|---|---|---|---|
| France | Service de maladies infectieuses et tropicales - Hôpitaux Universitaires de Strasbourg | Strasbourg |
| Lead Sponsor | Collaborator |
|---|---|
| University Hospital, Strasbourg, France |
France,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Description of patients treated with dual IV therapy combining cloxacillin and amoxicillin in high doses at Strasbourg University Hospital | Files analysed retrospectively from January 01, 2016 to December 31, 2020 will be examined] |
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