Acute Kidney Injury Clinical Trial
— AKDOfficial title:
Multidiscipline Care for Acute Kidney Injury to Chronic Kidney Disease Transition (Acute Kidney Disease) - a Randomized Controlled Study
The Taiwan Consortium of Acute Kidney Injury and Renal Diseases (TCTC) is leading a clinical trial group in Asia-Pacific to reduce the morbidity and mortality associated with acute kidney injury (AKI). The trial is a double two-by-two factorial design that will collect demographic and clinical information of AKI stage 2, 3, or weaning from dialysis-requiring AKI patients (AKI-D) to explore the epidemiology, risk factors and prognosis of AKI in Taiwan. Patients will be randomized either to add Angiotensin-Converting Enzyme Inhibitors (ACE-I)/Angiotensin II Receptor Blocker (ARB) to slow kidney function progression, or to receive multidisciplinary care. Patients will be followed up for a minimum of 6 months to evaluate kidney function, the predictability of developing chronic kidney disease, end stage renal disease, major cardiovascular events, and mortality.
Status | Recruiting |
Enrollment | 300 |
Est. completion date | February 15, 2024 |
Est. primary completion date | January 6, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 20 Years and older |
Eligibility | Inclusion Criteria: 1. Age = 20 years old on the day of index discharge 2. AKI develops during admission, as defined with KDIGO-AKI Guideline, namely, elevation of serum creatinine above 0.3mg/dL within two days, above 1.5 times baseline and ever receives dialysis during this index hospitalization. 3. Patients who has KDIGO-AKI stage 2, 3 or who could wean from dialysis requiring AKI-D in the index hospitalization. Exclusion Criteria: 1. Baseline estimated glomerular filtration rates (eGFR) less than 5ml/min/1.73m2 or greater than 90ml/min/1.73m2 according to MDRD equation after index discharge. 2. Patients receive further re-dialysis within 90 days after index hospital discharge, who are withdrawal for AKI-D. (sensors) 3. Previous gastrointestinal operations. 4. Patients with major hemorrhage, as defined with acute hemorrhage and requirement of blood transfusion during index admission. 5. Patients with a chronic lung disease requiring non-invasive or invasive positive pressure ventilation. 6. Solid organ or hematological transplantation donors. 7. Evidence of obstructive acute kidney injury. 8. Systolic blood pressure < 110mmHg. 9. Pregnant women |
Country | Name | City | State |
---|---|---|---|
Taiwan | Kaohsiung Medical University Hospital | Kaohsiung | |
Taiwan | Keelung CGMH | Keelung | |
Taiwan | China Medical University Hospital | Taichung | |
Taiwan | Taichung Veterans General Hospital | Taichung | |
Taiwan | National Taiwan University Hospital | Taipei | |
Taiwan | Taipei Veterans General Hospital | Taipei | |
Taiwan | Linkou Chang Gung Memorial Hospital | Taoyuan |
Lead Sponsor | Collaborator |
---|---|
National Taiwan University Hospital | Chang Gung Memorial Hospital |
Taiwan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Renal replacement therapy at any time after dialysis | Patients will followed up at any time after dialysis. | MAKE at 180 days | |
Primary | survival | Patients will followed up at any time after death. | MAKE at 180 days | |
Secondary | Rehospitalization | Rehospitalization from myocardial infarction, heart failure, arrhythmia, invasive cardiovascular interventions, cardiovascular causes after noncardiovascular surgery, stroke. | MAKE at 180 days |
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