The Performance of Renal Doppler Ultrasound in Predicting Outcome of Dialysis Weaning

Acute Kidney Injury Clinical Trial

Official title:

The Performance of Renal Doppler Ultrasound in Predicting Outcome of Dialysis Weaning

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04622384
• Other study ID #: 1-10-72-40-20(3)
• Status: Completed
• Start date: January 1, 2021
• Est. completion date: March 1, 2023

Study information

• Verified date: March 2024
• Source: Aarhus University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Acute kidney injury (AKI) is a frequent problem in the intensive care unit (ICU) affecting more than 50 % of patients. AKI is associated with several adverse outcomes, including increased mortality and increased length of ICU- and hospital stay, in particular in patients requiring Renal Replacement Therapy (RRT).

Choosing the optimal time for attempting liberation from RRT is still unclear. With this study, we will describe the ability of renal ultrasound in predicting the outcome of dialysis weaning.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 33
• Est. completion date: March 1, 2023
• Est. primary completion date: March 1, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• All patients = 18 years admitted to the ICU, Aarhus University Hospital who are treated with dialysis as continuous renal placement therapy (CRRT) and planned to undergo dialysis weaning

Exclusion Criteria:

• Insufficient ultrasonographic imaging of the kidneys

• Known morphological kidney disease

• Previous need of chronic RRT

• Prior participation in the study

• Need of extracorporeal membrane oxygenation (ECMO) or other heart assist device

Related Conditions & MeSH terms

• Acute Kidney Failure Stage 3
• Acute Kidney Injury
• Renal Insufficiency

Intervention

Other:
• Dialysis weaning
Dialysis weaning as planned by the attending ICU-physician.

Locations

Country	Name	City	State
Denmark	Aarhus University Hospital, Department of Anaesthesiology	Aarhus

Sponsors (1)

Lead Sponsor	Collaborator
Johan Fridolf Hermansen

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Dialysis weaning	If discontinuation of Dialysis is successful or not. Successful dialysis weaning is defined as no renal replacement therapy (RRT) required within the first 7 days after stopping continuous renal replacement therapy (CRRT) and non-successful weaning as the need for RRT within the first 7 days.	7 days
Secondary	Renal Doppler arterial Resistive Index (RI)	Measured in the interlobar vessels	Measured at the beginning of weaning and after 6 hours.
Secondary	Renal Doppler Renal Venous Stasis Index (RVSI)	Measured in the interlobar vessels	Measured at the beginning of weaning and after 6 hours.
Secondary	Renal Doppler Venous Impedance Index (VII)	Measured in the interlobar vessels	Measured at the beginning of weaning and after 6 hours.
Secondary	Portal vein Doppler Pulsatility Fraction PF)	Measured in the interlobar vessels	Measured at the beginning of weaning and after 6 hours.
Secondary	Urine Output		4 days
Secondary	Urine Creatinine Clearance		4 days