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Clinical Trial Summary

Septic shock continues to exert a large economic burden around the world. Several developments have occurred that lead to the current study. First, angiotensin II is the newest FDA approved vasopressor agent indicated for use in vasodilatory shock. Several subgroups from the approval trial have indicated that angiotensin II may confer a survival benefit in certain conditions, including those patients requiring continuous renal replacement therapy, those with altered angiotensin I: angiotensin II ratios, and most recently, those with elevated renin levels (which may serve as a surrogate for dysfunctional angiotensin 1: angiotensin II ratios). This open-label, sequential period pilot study will evaluate angiotensin II and biomarker response (renin) in the treatment of septic shock.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04558359
Study type Interventional
Source University of Kentucky
Contact Alexander H Flannery, Pharm.D.
Phone 859-562-2766
Email alex.flannery@uky.edu
Status Recruiting
Phase Phase 4
Start date October 19, 2020
Completion date July 31, 2023

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