Effects of Anesthetic Techniques on Renal Function

Acute Kidney Injury Clinical Trial

Official title:

Different Effects of Two Anesthetic Techniques on Renal Function During the Perioperative Period of Cardiac Surgery in Children

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04030481
• Other study ID #: DEOTATORFDTPPOCSIC
• Status: Completed
• Start date: January 1, 2019
• Est. completion date: September 30, 2019

Study information

• Verified date: October 2019
• Source: Children's Hospital of Fudan University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study evaluates Different effects of two anesthetic techniques on renal function during the perioperative period of cardiac surgery in children.

Description:

Acute kidney injury is one of the major complications after heart surgery, which increases the mortality of patients. Therefore, early prevention and detection of acute kidney injury is particularly important. In recent years, more and more studies have shown that both sevoflurane, an inhaled anesthetic widely used in clinical practice, and propofol, an intravenous anesthetic, have protective effects on kidneys. The aim of this study was to investigate the perioperative effects of two different anesthetic techniques on renal function for pediatric cardiac surgery.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: September 30, 2019
• Est. primary completion date: September 30, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A to 3 Years

Eligibility

Inclusion Criteria:

• children with congenital heart disease

• <3 years of age

Exclusion Criteria:

• preoperative renal insufficiency;

• renal malformation, kidney absence

Related Conditions & MeSH terms

• Acute Kidney Injury
• Congenital Heart Disease
• Heart Diseases

Intervention

Other:
• inhalation anesthesia
sevoflurane was used to maintain anesthesia
• Total intravenous anesthesia
propofol was used to maintain anesthesia

Locations

Country	Name	City	State
China	Children's Hospital of Fudan University	Shanghai	Shanghai

Sponsors (1)

Lead Sponsor	Collaborator
Huiying Shao

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	renal blood flow	Changes of blood flow information of renal artery was obtained before anesthesia induction, after anesthesia, at the end of operation and 24 hours after surgery, unit(cm/s)	2 days
Secondary	neutrophil gelatinase-associated lipocalin , NGAL	Changes of blood NGAL were obtained before and 2 hours after surgery, unit(ng/ml)	2 days
Secondary	creatinine	Changes of creatinine before and 3 days after acquisition, unit (mmol/L)	3 and 4 days
Secondary	Mean arterial pressure	Mean arterial pressure synchronized with renal blood flow was recorded, unit (mmHg)	2 days
Secondary	cardiopulmonary bypass (CPB) time	Cardiopulmonary bypass time was recorded, unit(minutes)	24 hours