Acute Kidney Injury Clinical Trial
Official title:
Doppler-based Renal Resistive Index in Assessing Renal Dysfunction Reversibility in ICU Patients
Acute kidney injury (AKI) is common in intensive care unit (ICU) patients and remains
associated with a dismal prognosis. The diagnosis of AKI relies on functional criteria
(oliguria and serum creatinine elevation), which carry several important limitations.
Additionally, the investigators lack biomarker that may predict short term renal prognosis.
Doppler-based renal resistive index (RI) measurement is a rapid and noninvasive
investigative tool that may hold promise for early AKI detection in ICU patients or in
differentiating transient from persistent AKI in selected critically ill patients. Although
several studies have suggested adequate performance in predicting short-term reversibility
of AKI, most of these studies were performed in limited patient samples. Additionally, a
recent study has identified discrepant results regarding its diagnostic performance.
The main objective of this large prospective multicentre study is to assess diagnostic
performance of Doppler-based renal resistive index in diagnosing persistent AKI in
critically ill patients requiring mechanical ventilation.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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