Acute Kidney Injury Clinical Trial
Official title:
Effect of Aminophylline on Contrast Induced Acute Kidney Injury in Patients With Acute Myocardial Infarction Treated With Primary Angioplasty
The purpose of this study is to determine whether additional therapy with Aminophylline to hydration with sodium bicarbonate and administration of N-acetylcysteine is more effective to prevent contrast induced acute kidney injury in patients undergoing primary coronary intervention for acute ST elevation myocardial infarction.
Due to the clinical relevance of contrast acute kidney injury a large number of prophylactic
procedures have been investigated. N-acetylcysteine and hydration with sodium bicarbonate
are proved to be protective against contrast acute kidney injury. The adenosine-mediated
afferent arteriolar vasoconstriction is a possible pathomechanism of renal impairment by
contrast agent. It has been observed that aminophylline/theophylline, competitive adenosine
antagonists, improves oxygen delivery to ischemic tissue, diminishes oxidative damage to
renal tissue and may also scavenge free radicals.
The purpose of this study was to investigated whether the additional therapy with adenosine
antagonist aminophylline reduces the incidence of contrast renal damage in high risk
patients who have acute myocardial infarction.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Prevention
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