Acute Kidney Injury as a Risk Factor for Myocardial Injury After Non Cardiac Surgery

Acute Kidney Injury (AKI) Clinical Trial

Official title:

Assessment of Acute Kidney Injury as a Risk Factor for Myocardial Injury After Non Cardiac Surgery in Critical Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05068167
• Other study ID #: ACI after non cardiac surgery
• Status: Completed
• Start date: March 1, 2019
• Est. completion date: September 30, 2020

Study information

• Verified date: September 2021
• Source: South Egypt Cancer Institute
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The incidence of acute kidney injury (AKI) postoperatively has been identified to be 21.6% in adults and 18.3% in hospitalized individuals. Surgery-related AKI is a severe complication that is related not only to short-term complications as increases in mortality rate and development of cardiac complications but also with complications on long term, such as development of chronic kidney disease. A better understanding of the mechanism of this hypthesis will lead to better management of this complication.

Description:

A randomized blinded prospective study included 206patients who the candidate for major surgery at South Egypt Cancer Institute, Assiut University, Assiut, Egypt. From April 2018 till April 2019, a detailed history and careful examination, routine laboratory investigations were done, Baseline ECG was recorded 24hours before surgery and 48hours postoperative at ICU.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 240
• Est. completion date: September 30, 2020
• Est. primary completion date: August 30, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• patients who were candidates for major non cardiac surgery

Exclusion Criteria:

• chronic cardiac diseases (myocardial ischemia, heart failure), Active severe infection, pregnancy, chronic kidney disease

Related Conditions & MeSH terms

• Acute Kidney Injury
• Acute Kidney Injury (AKI)
• Wounds and Injuries

Intervention

Diagnostic Test:
• Kidney function test
Creatinine twice the baseline and urine output of fewer than 0.5 ml/kg per hour for 12 hours

Locations

Country	Name	City	State
Egypt	Alaa Ali Elzohry	Assuit

Sponsors (1)

Lead Sponsor	Collaborator
South Egypt Cancer Institute

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Creatinine level	Creatinine twice the baseline and urine output of fewer than 0.5 ml/kg per hour for 12 hours	every 12 hours