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Effect of CVP and IOH on AKI and AKD

Acute Kidney Injury Clinical Trial

Official title:
Venous Congestion Rather Than Intraoperative Hypotension is Associated With Acute Adverse Kidney Events After Cardiac Surgery

Clinical Trial Summary

This study was aimed to explore the effect of intraoperative venous congestion and intraoperative hypotension (IOH) on acute adverse kidney events, defined as acute kidney injury (AKI) and acute kidney disease (AKD), after cardiac surgery

Clinical Trial Description

Venous congestion and IOH were primary exposures and quantified as area under the curve (AUC) of central venous pressure ≥12, 16 or 20 mmHg or mean arterial pressure ≤55, 65, 75 mmHg. The primary outcome was AKI or AKD defined as renal dysfunction persisting > 7 days after surgery. Multivariable logistic regression and Cox proportional hazard models were used to determine the association between intraoperative venous congestion/hypotension and postoperative acute adverse kidney events, respectively, adjusted for relevant confounding factors and multiple comparisons. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05222074
Study type Observational
Source Nanjing First Hospital, Nanjing Medical University
Contact
Status Completed
Phase
Start date June 1, 2016
Completion date August 1, 2021
View Details
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