Magnetic Resonance Post-contrast Vascular Hyperintensities at 3 T: a Sensitive Sign of Vascular Occlusion in Acute Ischaemic Stroke

Acute Ischaemic Stroke Clinical Trial

Official title:

Magnetic Resonance Post-contrast Vascular Hyperintensities at 3 T: a New Highly Sensitive Sign of Vascular Occlusion in Acute Ischaemic Stroke

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03971526
• Other study ID #: 29426989
• Status: Completed
• Start date: September 1, 2014
• Est. completion date: September 1, 2016

Study information

• Verified date: May 2019
• Source: Fondation Ophtalmologique Adolphe de Rothschild
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Magnetic resonance imaging (MRI) is the diagnostic cornerstone for precisely identifying acute ischaemic strokes and locating vascular occlusions.

It was observed that a post-contrast three-dimensional turbo-spin-echo T1weighted sequence showed striking post-contrast vascular hyperintensities (PCVH) in ischaemic territories. The aim is to evaluate the prevalence and the meaning of this finding.

This study included 130 consecutive patients admitted for acute ischaemic stroke with a 3-T MRI performed in the first 12 h of symptom onset from September 2014 through September 2016. Two neuroradiologists blinded to clinical data analysed the first MRI assessments.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 130
• Est. completion date: September 1, 2016
• Est. primary completion date: September 1, 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion criteria:

• Patients aged 18 and older at onset of an acute ischaemic stroke

• Availability of at least one pre-therapeutic MRI performed in our centre within 12 h of stroke onset, including a post-contrast 3D TSE T1-weighted sequence.

Exclusion criteria:

• Patients with posterior fossa strokes

• Patients with known intracranial vasculitis or MoyaMoya disease

• Presence of severe MR imaging artefacts preventing correct interpretation

Related Conditions & MeSH terms

• Acute Ischaemic Stroke
• Cerebral Infarction
• Ischemia
• Stroke

Intervention

Other:
• MRI images review
MR images were reviewed by one junior radiologist and one senior neuroradiologist, both blinded to clinical, therapeutic and follow-up data.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Fondation Ophtalmologique Adolphe de Rothschild

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	overal survival	from the AR-PML diagnosis date to that of death or censored on 31 December 2015	7 years