Clinical Trials Logo

Acute Graft Rejection clinical trials

View clinical trials related to Acute Graft Rejection.

Filter by:
  • Completed  
  • Page 1

NCT ID: NCT02633826 Completed - Clinical trials for Kidney Transplantation

Pre-formed Alloreactivity in Renal Transplant Recipients

Start date: November 2015
Phase:
Study type: Observational

This investigator-initiated study will analyse the role of pre-formed alloreactive T cells on acute rejection episodes and graft outcome in kidney transplant recipients after living donation.

NCT ID: NCT02597543 Completed - Heart Transplant Clinical Trials

Stress Cardiac MRI for Evaluation of Nonspecific Allograft Dysfunction

Start date: November 2015
Phase: Phase 4
Study type: Interventional

The investigators will use cardiac MRI to measure the myocardial perfusion reserve and amount of myocardial edema and fibrosis in heart-transplant patients with nonspecific allograft dysfunction in contrast to those with normal graft function. The investigators hypothesize that patients with nonspecific allograft dysfunction will demonstrate decreased myocardial perfusion reserve, related to microvascular allograft vasculopathy, compared to those with normal graft function.

NCT ID: NCT02581436 Completed - Clinical trials for Renal Transplant Rejection

Testing Immunosuppression Threshold in Renal Allografts To Extend eGFR

TITRATE
Start date: September 2014
Phase: N/A
Study type: Interventional

This study evaluates the addition of "Kidney Solid Organ Rejection Test" (kSORT), in the clinical follow-up of renal transplant recipients, compared to clinical standard surveillance in the first two years after kidney transplantation. The design of the study is a partially blinded, randomized control trial of patients with living and deceased donor. The recruitment will be in a third level attention hospital in Mexico city (Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán). The main outcomes are the rate and grade of acute rejection, histologic chronic index of the one year protocol biopsy and glomerular filtration rate.

NCT ID: NCT02261870 Completed - Clinical trials for Heart Transplantation

Detection of Acute Graft Rejection in Heart Transplant Patients by Estimation of T2

DRAGET
Start date: February 18, 2015
Phase: N/A
Study type: Interventional

The investigators propose a simple and non-invasive method to monitor heart transplant patients with MRI. Its diagnostic and prognostic values have already been assessed in two monocentric studies. Other monocentric studies based on related methods have confirmed the investigators findings. These studies are insufficient to allow a large diffusion of the technique. Only a large multi-centric study will change medical practices. In addition, this project will spread the new method at a national level and will allow an assessment of its practical usefulness in centres not familiar with MRI T2 quantification. Furthermore, MRI seems to detect rejections at earlier stage than biopsy. A confirmation of this observation could lead to a modification of diagnostic criteria of cardiac graft rejection. The ultimate aim of the DRAGET project is to replace a strategy based solely on biopsy with one based on a first-line MRI (with biopsy only when needed) for a more efficient and earlier detection of rejection. This would constitute a major advance in patients security and comfort as well as an economic improvement.

NCT ID: NCT01265537 Completed - Diabetes Clinical Trials

A Pilot Study Comparing the Use of Low-target Versus Conventional Target Advagraf

Astellas
Start date: June 24, 2011
Phase: N/A
Study type: Interventional

While the incidence of acute rejection and early graft loss have improved dramatically with the advent of newer immunosuppressant medications, improvements in long-term patient and allograft survival after kidney transplantation have not been achieved. The specific drug combination that provides the best outcomes with the least amount of side effects is not known. Each kidney transplant center uses the combination of drugs that they believe is optimal. This study is about identifying whether drugs that are currently approved for use in kidney transplantation can be used in a new combination safely and with potentially fewer side effects than the drug combinations that are currently used at St. Paul's Hospital and other transplant centres.

NCT ID: NCT00321906 Completed - Clinical trials for Delayed Graft Function

Comparison of Sirolimus and Azathioprine in Lung Transplantation

Start date: April 2002
Phase: Phase 4
Study type: Interventional

The purpose of this study is to compare the safety and effectiveness of two different anti-rejection drug regimens.