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Acute Exacerbation Copd clinical trials

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NCT ID: NCT06143150 Not yet recruiting - Clinical trials for Acute Exacerbation COPD

Prediction of Outcome of Non Invasive Ventilation COPD Patients by Assessment of Diaphragmatic Performance

Start date: November 15, 2023
Phase:
Study type: Observational

Transthoracic ultrasonographic assessment of the diaphragmatic performance as a predictor for the outcome of NIV in critically ill COPD patients with acute exacerbation.

NCT ID: NCT06123780 Not yet recruiting - Clinical trials for Acute Exacerbation COPD

Pattern of Microbial Infection in AECOPD Patients and Its Sensitivity to Antibiotics

Start date: December 1, 2023
Phase:
Study type: Observational

Measurement of bacterial species causing AECOPD and their Sensitivity pattern to antibiotics.

NCT ID: NCT03823443 Terminated - Clinical trials for Chronic Obstructive Pulmonary Disease

COPD Exacerbation Blood and Urine Biomarkers Study

Start date: June 7, 2018
Phase:
Study type: Observational

This will be a prospective study examining serum levels of MMP-13 and alpha-1 antitrypsin as well as other biomarkers as well as urine biomarkers of smoking status and collagen degradation in the COPD patient population. Serum and urine biomarkers at baseline and after COPD exacerbations will be assessed against change in lung function as measured by pulmonary function testing.

NCT ID: NCT03466385 Recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

NHF vs NIV in Patients With Acute Exacerbation of COPD

Start date: April 15, 2018
Phase: N/A
Study type: Interventional

Although non-invasive ventilation (NIV) usage has increased significantly over time in COPD exacerbation, a great percentage of patients (~30%) present contraindications to NIV or cannot tolerate it. Nasal high flow (NHF) has been introduced for the management of hypoxemic respiratory failure in adults with favorable effects on ventilation and respiratory mechanics. The above mentioned NHF positive effects has been observed also in stable COPD patients with or without chronic hypercapnia. In this study, the investigators hypothesize that NHF is not inferior to NIV for respiratory support in patients with COPD exacerbation and acute or acute on chronic hypercapnic respiratory failure.

NCT ID: NCT03440060 Recruiting - Clinical trials for Acute Exacerbation Copd

Procalcitonin-guided Antibiotic Therapy During Severe Exacerbation of COPD

Start date: October 5, 2017
Phase: N/A
Study type: Interventional

This study assess whether a procalcitonin guided antibiotic therapy can reduce significantly unnecessary antibiotic prescription during severe exacerbation of COPD requiring mechanical ventilation without compromising patients' outcome. The first group of patients will receive systematically empiric antibiotic therapy and the second group will receive antibiotics only if procalcitonin value is at or greater than 0.25 ng/ml.

NCT ID: NCT03277001 Not yet recruiting - Clinical trials for Venous Thromboembolism

Study of Prophylactic Effect of Rivaroxaban on Venous Thromboembolism in AECOPD

SUPREME
Start date: October 1, 2017
Phase: N/A
Study type: Interventional

AECOPD increases the risk of VTE.VTE prevention is a long way to go for high-risk VTE patients in China.The incidence of AECOPD complicated with VTE in Asian population is high and the mortality rate is high.Rivaroxaban, a new oral anticoagulant, has been widely used in the treatment and prevention of VTE.However the question about the efficacy and safety of new oral anticoagulant compared with LMWHs for the prevention of symptomatic VTE and VTE-related death post-hospital discharge in high-risk AECOPD patients is still unknown. Thus this study is to evaluate if the prophylactic anticoagulation effect by Rivaroxaban is non-inferiority than Enoxaprine in high risk AECOPD and to evaluate the safety of using Rivaroxaban to prevent VTE in high risk AECOPD comparing with Enoxaprine.

NCT ID: NCT03079661 Terminated - Clinical trials for Acute Exacerbation Copd

Impact of Air Quality on Exacerbations of COPD in the Somme

PolluBPCO
Start date: January 1, 2017
Phase:
Study type: Observational

All COPD patients with a diagnosis of acute exacerbation in emergency room in University Hospital of Amiens-Picardie between 01/01/2017 and 31/12/2017. The investigator will collect for each patient the home address and the work address. The duration of 1 year was chosen to take into account seasonal variations. In parallel, a daily report of the rate of ozone, particles (PM2.5 and PM10), dioxide nitrogen but also odours and pollens will be done by ATMO Picardie.