Acute Diverticulitis Clinical Trial
Official title:
Procalcitonin REveals Good Recovery After Acute Diverticulitis: the PREGRAD Study
Diverticular disease is a common disease in developed countries, affecting 2.5 million
individuals in the United States (US). Prevalence of diverticula increases with age and goes
up to 50 to 66% in patients older than age 80 years. Approximately 10 to 25% of patients
with diverticulosis will develop diverticulitis. Acute diverticulitis (AD) accounts for
312,000 admissions and 1.5 million days of inpatient care in the US, where its annual
treatment costs exceed 2.6 billion dollars. With the ageing of global population these
numbers are expected to rise.
Procalcitonin (PCT) is a biomarker widely used to monitor bacterial infections and guide
antibiotic therapy in Intensive Care Units and has been shown to be useful in different
surgical fields such as acute appendicitis. Recently, has been demonstrated that PCT and CPR
have good predictive value of anastomotic leak (AL) after colorectal surgery.
A multicentric study has been designed to test if PCT, CRP and WBC values might be able to
predict the outcomes of patients admitted in emergency setting for acute diverticulitis. In
particular if they might distinguish between patients needing only conservative (nothing per
os, iv fluids and antibiotics) or interventional therapy such as radiological drain or even
surgery, in the aim to optimize and individualize each patients therapy and speed patients
discharge.
n/a
Observational Model: Case-Only, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02785549 -
Randomized Clinical Trial to Compare the Treatment of Mild Acute Diverticulitis With or Without Antibiotics
|
Phase 4 | |
| Completed |
NCT03008707 -
Laparoscopic Peritoneal Lavage vs Laparoscopic Sigmoidectomy in Perforated Acute Diverticulitis: a Multicenter Prospective Observational Study (STELLA Study)
|
||
| Recruiting |
NCT04407793 -
Prospective and Multicentre Study on Clinical-biological Factors Predictive of Chronic Colon DIverticulitis
|
||
| Completed |
NCT03279588 -
Diagnostic Accuracy of Bedside Ultrasound in Suspected Acute Diverticulitis
|
||
| Recruiting |
NCT06023004 -
The Diverticulitis Study
|
||
| Not yet recruiting |
NCT06388538 -
The COLD2B Multicenter, Two-arm Prospective Cohort Study
|
||
| Recruiting |
NCT06109506 -
Towards a Tailored Approach for Patients With Acute Diverticulitis and Abscess Formation. A Multicenter Cohort Analysis
|
||
| Recruiting |
NCT03643718 -
Web-based International Register of Emergency Surgery and Trauma
|
||
| Recruiting |
NCT04596280 -
Comparision Among Classifications for Acute Diverticulitis: a Multicenter Study
|
||
| Recruiting |
NCT06265649 -
Comparison of NOM for ACLD Between Medical and Surgical Ward
|
||
| Recruiting |
NCT06344078 -
Surgical Italian Guide for the Management of Complicated Acute Diverticulitis Emergency Setting (SIGMA-D). A Prospective Observational Multicenter Study on Behalf of the Italian Society of Colorectal Surgery (SICCR).
|
||
| Completed |
NCT04663490 -
Neutrophil to Lymphocyte Ratio as a Predictor of Complicated Acute Diverticulitis
|
||
| Recruiting |
NCT05162560 -
Incidence and Outcome of Acute Diverticulitis in Finland
|
||
| Enrolling by invitation |
NCT05085353 -
Fetal Outcomes Among Pregnant Emergency General Surgery Patients
|
||
| Completed |
NCT01840852 -
Sleep and Cytokines During Acute Diverticulitis
|
N/A | |
| Not yet recruiting |
NCT01825967 -
Acute Diverticulitis and C-Reactive Protein as a Prognostic Marker
|
N/A | |
| Completed |
NCT01840917 -
Heart Rate Variability During Acute Diverticulitis
|
N/A | |
| Completed |
NCT01609751 -
Prevention of Diverticulitis by Taking a Daily Probiotic
|
N/A | |
| Completed |
NCT01840878 -
Validation of Actigraph Measured Sleep During Acute Diverticulitis
|
N/A | |
| Completed |
NCT01840904 -
Subjective Sleep and Fatigue During and After Acute Diverticulitis
|
N/A |