Acute Diverticulitis Clinical Trial
Official title:
Multicentre Controlled, Randomized Clinical Trial to Compare the Efficacy and Safety of Ambulatory Treatment of Mild Acute Diverticulitis Without Antibiotics With the Standard Treatment With Antibiotics
Patients with mild acute diverticulitis (modified Neff 0 grade), following the inclusion criteria and giving informed consent, will be included in the study protocol and will be randomly assigned to one of the treatment arms: symptomatic treatment with NSAID plus antibiotic vs symptomatic treatment with NSAID only. They will be followed-up at 48 hours, 7 days, 30 days and 3 months from the onset of the episode.
In the last years, traditional pathologic mechanisms of acute diverticulitis are being
questioned and replaced by more scientifically grounded hypotheses that strongly postulate an
inflammatory origin. Local pro-inflammatory cytokines, microbiota shifts, disturbed
neurological intestinal signalling due to alterations in colonic neuropeptides and abnormal
colonic motility are all being proposed as potential etiologic factors. Recent publications,
therefore, call into question the benefits of antibiotic treatment or episodes of acute
diverticulitis, especially for mild episodes. Furthermore, recent international guidelines
endorse this stance in their recommendations. Moreover, recent studies provide evidence
regarding the security of treating patients with mild acute diverticulitis as outpatients.
The investigators think that outpatient treatment without antibiotic for mild acute
diverticulitis is not-inferior to traditional treatment with antibiotic, measuring the
efficacy with readmission ratio. For this reason we have designed a multicentric, randomised,
prospective study.
All patients seen in the emergency department with clinical signs of acute diverticulitis
(left iliac fossa abdominal pain, peritoneal irritation signs and/or leucocytosis) will
undergo an abdominal computed tomography to confirm the diagnosis and grade the disease
according to severity using the modified Neff (mNeff) classification. Those with mild acute
diverticulitis (grade 0), following the inclusion criteria and giving informed consent, will
be included in the study protocol and will be randomly assigned to one of the treatment arms:
symptomatic treatment with NSAID plus antibiotic vs symptomatic treatment with NSAID only.
They will be followed-up at 48 hours, 7 days, 30 days and 3 months from the onset of the
episode.
Primary goal is to determine if, in mild acute diverticulitis, the treatment without
antibiotic is not-inferior to the traditional treatment with antibiotic considering
readmission ratio.
Secondary goals include the analysis of the differences between groups, in case there are, in
relation to number and reason for reconsultation, reason for readmission (bad symptoms
control, radiologic progression, analysis worsening), pain control (analogic visual scale),
recuperation after the acute episode, complication rate and their treatment.
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