Subjective Sleep and Fatigue During and After Acute Diverticulitis

Acute Diverticulitis Clinical Trial

Official title: Subjective Sleep Quality and Fatigue During and After Acute Uncomplicated Diverticulitis

Status Completed

Clinical Trial Summary

The purpose of this study is to investigate subjective sleep quality and fatigue during and after Acute uncomplicated diverticulitis assessed by questionnaires and a sleep-diary. The investigators hypothesis is that subjective sleep and fatigue are correlated with the inflammatory activities.

Clinical Trial Description

An increasing number of experimental studies have showed that inflammation can induce disturbances in sleep architecture, mediated by cytokines. some studies showed that cytokines also induce daytime fatigue. In this study the investigators aim to describe the patient experiences of sleep and fatigue during the acute inflammation and the recovery, and the investigators seek to exam the correlation of fatigue with Polysomnography-measured night sleep and cytokine levels in plasma.

Following methods will be applied

• Other: Karolinska Sleepiness Scale

• Other: Physical Fatigue Scale

• Other: Visual Analog Scale and 10 point-scales to measure fatigue, general well-being, subjective sleep and pain

• Other: Sleep-diary

• Device: Polysomnograph - Embla Titanium (Natus Medical Incorporated, USA)

• Procedure: Plasma cytokines (IL-2, IL-6 and TNF-alfa(tumor necrosis factor))

• Procedure: Plasma CRP(C reactive protein) and leukocytes

• Device: Wrist-Actigraph - Octagonal Basic Motionlogger, Ambulatory monitoring Inc, New York, USA ;

Study Design

Observational Model: Case-Crossover, Time Perspective: Prospective

Related Conditions & MeSH terms

• Acute Diverticulitis
• Diverticulitis

• NCT number: NCT01840904
• Study type: Observational
• Source: Herlev Hospital
• Status: Completed
• Phase: N/A
• Start date: April 2013
• Completion date: November 2013