Acute Diverticulitis Clinical Trial
Official title:
the Effects of Inflammatory Cytokines on Sleep During Acute Diverticulitis
The purpose of this study is to investigate sleep disturbances during Acute uncomplicated diverticulitis by polysomnography. The investigators hypothesis is the inflammation causes REM(rapid eye movement)-sleep reduction and this is correlated with plasma cytokine levels.
An increasing number of experimental studies have showed that inflammation can induce
disturbances in sleep architecture, mediated by cytokines. Sleep is important both in health
and disease processes and can affect recovery, morbidity and mortality.
Studies have been done on sleep disturbances after major and minor GI-surgery but never in
relation to none surgical inflammatory diseases, namely acute diverticulitis.
This study will investigate sleep architecture by Polysomnography and inflammation by levels
of pro inflammatory cytokines in plasma.
Following methods will be applied
Device: Polysomnograph - Embla Titanium (Natus Medical Incorporated, USA)
Procedure: Plasma cytokines (IL-2, IL-6 and TNF(tumor necrosis factor-alfa)
Procedure: Plasma CRP(C reactive protein) and leukocytes
;
Observational Model: Case-Crossover, Time Perspective: Prospective
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