Clinical Trials Logo

Clinical Trial Summary

- Acute diarrhea continues to be a major cause of childhood morbidity and mortality in developed and developing countries.

- Prevention and treatment of dehydration are the mainstays of therapy. Rehydration can be achieved with oral rehydratation solution (ORS).

- Even though ORS has reduced the mortality and morbidity very significantly, it has no effect on the duration of diarrhea, stool consistency and frequency and remains underused.

- ESPGHAN and ESPID published together an evidence based guideline and stated that in the management of acute gastroenteritis rehydration is the key treatment and that selected probiotics may reduce the duration and intensity of symptoms and can be used as an adjuvant to ORS.

- Current evidence also indicates that probiotic effects are strain-specific. Lactobacillus GG and Saccharomyces boulardii are the best studied strains. However, more research is needed to guide the use of particular probiotic regimens and strains and as there is still no evidence of efficacy for many preparations.


Clinical Trial Description

Acute diarrhea continues to be a major cause of childhood morbidity and mortality in developed and developing countries. Prevention and treatment of dehydration are the mainstays of therapy. Rehydration can be achieved with oral rehydratation solution (ORS). Even though ORS has reduced the mortality and morbidity very significantly, it has no effect on the duration of diarrhea, stool consistency and frequency and remains underused. ESPGHAN and ESPID published together an evidence based guideline and stated that in the management of acute gastroenteritis rehydration is the key treatment and that selected probiotics may reduce the duration and intensity of symptoms and can be used as an adjuvant to ORS. A recent Cochrane review including 56 trials in children concluded that speciļ¬c probiotics reduce the duration of diarrhea with about 24 hours and decrease the frequency of defecation on the second day. Current evidence also indicates that probiotic effects are strain-specific. Lactobacillus LGG and Saccharomyces boulardii are the best studied strains. However, more research is needed to guide the use of particular probiotic regimens and strains and as there is still no evidence of efficacy for many preparations. The aim of this study was to evaluate effects of different probiotics on the duration of acute infectious diarrhea. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT01927094
Study type Interventional
Source Eskisehir Osmangazi University
Contact
Status Completed
Phase Phase 4
Start date June 2012
Completion date January 2015

See also
  Status Clinical Trial Phase
Completed NCT04039828 - Zinc Sulfate Acceptability N/A
Completed NCT03943654 - Improving Nighttime Access to Care and Treatment (Part 2)
Completed NCT01577043 - Efficacy of Racecadotril in Acute Watery Diarrhea in Children Phase 4
Not yet recruiting NCT03598010 - Safety, Tolerability and Preliminary Efficacy of Lenodiar Pediatric in Diarrhea N/A
Completed NCT03684538 - Efficacy Of Probiotics vs. Zinc vs. Probiotics-Zinc Combination On Acute Diarrhea In Children N/A
Terminated NCT02817165 - Probiotics for the Prevention of Antibiotic-Associated Diarrhea N/A
Completed NCT04237181 - Results of FilmArray® Gastro-intestinal Panel and Serum Procalcitonin in Acute Colitis and Infectious Diarrhea in the ER N/A
Completed NCT05345028 - Boswellia Serrata Extract in Acute Diarrhea N/A
Completed NCT01814202 - Study With Medical Nutrition Product PTM202 in Pediatric Diarrhea N/A
Completed NCT02896465 - Human Milk Oligosaccharides and Childhood Diarrhoea N/A
Completed NCT04796480 - Comparison Of Outcome Of Lactose Free Formula Milk With Yogurt In Children With Acute Diarrhea N/A
Completed NCT01571856 - Efficacy of Use of Zinc in the Treatment of Acute Diarrhea in Infants Phase 4
Completed NCT01269892 - Early Administration of Lactose-free Milk in Children Presenting With Acute Diarrhea Phase 2
Completed NCT00429325 - Fecal Calprotectin: Cheap Marker for Diagnosing Acute Infectious Diarrhea N/A
Recruiting NCT05183789 - IL6&8 in Malnourished Children With Acute Diarrhea
Completed NCT01564290 - Use of Probiotic Yogurt in the Treatment of Acute Diarrhea in Children Phase 4
Recruiting NCT05213325 - Evaluation of Serum Interleukin 6 and 8 in Children With Acute Gastroenteritis
Unknown status NCT01273012 - Cost-effectiveness of Infloran (TM) in Treating Acute Childhood Diarrhea in Phramongkutklao Hospital N/A
Completed NCT03356327 - Oral Administration of Tannins and Flavonoids in Children With Acute Diarrhea Phase 4