Clinical Trials Logo
  1. Home
  2. Acute Coronary Syndromes
  3. NCT04630288

Safety and Efficacy of Ticagrelor vs Clopidogrel in Patients With Acute Coronary Syndrome

Acute Coronary Syndromes Clinical Trial

Official title:
ANTIPLATELET TREATMENT IN ACUTE CORONARY SYNDROMES. SAFETY AND EFFICACY OF ANTIPLATELET SWITCHING Safety and Efficacy of Ticagrelor vs Clopidogrel in Patients With Acute Coronary Syndrome

Clinical Trial Summary

Multicenter post-approval observational retrospective cohort study in routine clinical practice (Real World Evidence Study) to assess the 1-year safety profile associated with ticagrelor and clopidogrel therapy in a contemporary reprospective cohort of patients who survived the initial 30-day period after the index hospitalization for acute coronary syndrome (ACS).

Clinical Trial Description

To date, there are still a paucity of data on the medium- and long-term safety and efficacy outcomes of new antiplatelet agents, namely Ticagrelor and Prasugrel, compared to Clopidogrel in a real-world ACS setting. The ARIAM-Andalusia multicentre Registry, and the CREA-ARIAM multicentre Registry (ClinicalTrials.gov Identifier: NCT02500290; Fundación Pública Andaluza Progreso y SaludIdentifier: FPS-AAS-2014-01), are two Real World Evidence (RWE) studies aimed to investigate real-world practice on antiplatelet treatment in patients with ACS in Andalusia (Western Spain). Our group are interested in performing a retrospective observational pilot analysis using data from patients with ACS admitted to cardiovascular intensive care units in Andalusia (Spain), who were prospectively included in the ARIAM-Andalusia multicentre Registry, and the CREA-ARIAM multicentre Registry (ClinicalTrials.gov Identifier: NCT02500290; Fundación Pública Andaluza Progreso y Salud-Identifier: FPS-AAS-2014-01) between 2014 and March 2019. The main findings from the RWE study revealed a consistent net clinical benefit of Ticagrelor vs Clopidogrel resulted in a significant reduction of short-term all-cause mortality favored Ticagrelor. In this scenario, after baseline imbalance adjustment using propensity score matching (PSM) and IPTW (inverse probability of treatment weight) methods, the net clinical benefit with Ticagrelor persisted. Preliminary results of the above mentioned study have been presented as an oral communication at the Annual Scientific Meeting of the Spanish Society of Cardiology (Madrid, October 2017). The aim of this new pilot study suggested is to describe the efficacy and safety of Ticagrelor vs Clopidogrel after the first 30 days from hospital discharge and up to 1 year follow-up. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04630288
Study type Observational
Source Andalusian Network for Design and Translation of Advanced Therapies
Contact
Status Active, not recruiting
Phase
Start date July 2, 2019
Completion date December 31, 2020
View Details
See also
  Status Clinical Trial Phase
Completed NCT02552407 - Thrombectomy in ST Elevation Myocardial Infarction, an Individual Patient Meta-analysis N/A
Completed NCT01398228 - Clinical Pathways for the Management of Acute Coronary Syndromes - Phase 3,CPACS-3 N/A
Completed NCT01135667 - Prasugrel Versus Double Dose Clopidogrel to Treat Clopidogrel Low-responsiveness After PCI Phase 4
Recruiting NCT02592720 - Cocktail Injection Improves Outcomes of FFR Guided PCI Phase 4
Completed NCT01641510 - PRAsugrel or clopIdogrel In Acute Coronary SyndromE With CYP2C19 GENEtic Variants Phase 3
Completed NCT01743274 - Does Optical Coherence Tomography Optimise Results of Stenting N/A
Active, not recruiting NCT01433627 - Minimizing Adverse Haemorrhagic Events by TRansradial Access Site and Systemic Implementation of angioX Phase 3
Completed NCT01452282 - Ankle-Brachial Index Estimating Cardiac Complications After Surgery N/A
Recruiting NCT01418794 - Efficacy and Safety of the YUKON Drug Eluting Stent in Diffuse Coronary Artery Disease Phase 4
Recruiting NCT01000701 - Inflammation and Acute Coronary Syndromes N/A
Terminated NCT01107899 - Study to Learn When Platelets Return to Normal After One Loading Dose of Anti-platelet Drugs in Patients With Symptoms of Acute Coronary Syndromes Phase 1
Completed NCT00494247 - Endothelial Progenitor Cells-capture Stents in Acute Coronary Syndromes Phase 4
Terminated NCT00615719 - Computed Tomographic Coronary Angiography for Acute Chest Pain Evaluation N/A
Active, not recruiting NCT06089343 - High-risk Features of Coronary Lesions in CTA and OCT
Not yet recruiting NCT04023630 - DUAL Antithrombotic Therapy in Patients With AF and ACS Phase 4
Recruiting NCT02601404 - REal World Advanced Experience of BioResorbable ScaffolD by SMart Angioplasty Research Team (SMART REWARD) N/A
Completed NCT02195193 - Integrating Depression Care in Acute Coronary Syndromes Care in China N/A
Not yet recruiting NCT01735227 - Omeprazole and Pantoprazole Antiplatelet Effect of Clopidogrel Clinical Trials(OPEN) Phase 4
Completed NCT02141750 - THIRD NATIONAL REGISTRY OF ACUTE CORONARY SYNDROMES N/A
Completed NCT00097591 - A Comparison of Prasugrel (CS-747) and Clopidogrel in Acute Coronary Syndrome Subjects Who Are to Undergo Percutaneous Coronary Intervention Phase 3