Sickle Cell Disease Clinical Trial
Official title:
Secretory Phospholipases A2 in Exhaled Breath Condensate From Sickle Cell Patients With Acute Chest Syndrome: A Feasibility Study
Secretory phosholipases A2 (sPLA2) are significantly elevated in the plasma of sickle cell disease patients with acute chest syndrome (ACS), and similar enzymes have been measured in exhaled breath condensate (EBC), which is collected easily and non-invasively. The investigators hypothesize that sPLA2 will be measurable in EBC samples from sickle cell patients with acute chest syndrome.
The purpose of this research study is to test the ease and effectiveness of collecting
exhaled breath condensate (liquid) to measure levels of a biomarker, secretory phospholipases
A2 (sPLA2) in people with sickle cell disease during an attack of acute chest syndrome. sPLA2
levels have been reported to be much higher in persons with acute chest syndrome and might be
useful to diagnose and to evaluate the effects of therapy.
Serial monitoring of plasma sPLA2 levels might lead to earlier or more accurate detection of
acute chest syndrome and monitoring of its progression or improvement in patients with sickle
cell disease. However, there is a significant inherent risk of frequent blood collection
further dropping the blood (hemoglobin) levels of an already anemic patient. If sPLA2 can be
measured in exhaled breath condensate, this non-invasive and well-tolerated sample collection
might allow for serial monitoring of the enzyme without depleting the patient's already
diminished blood supply.
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