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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT03032055
Other study ID # Presev 2 IRB 00003835
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date January 1, 2016
Est. completion date December 31, 2023

Study information

Verified date December 2022
Source Soutien aux Actions contre les Maladies du Globule Rouge
Contact DJOUMAD Sabrina, Master's
Phone 33 (1) 49812441
Email sabrina.djoumad@aphp.fr
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Vaso-Occlusive Crisis (VOC), the most common manifestation of sickle cell disease (SCD), is the first cause of death, particularly when complicated by an acute chest syndrome (ACS). The PRESEV score could help the physicians to better manage VOC and could be used for future therapeutic trials. This predictive score of secondary ACS has to be validated in a multicenter international study.


Description:

International multicentre prospective observational study. Prediction of an ACS within 15 days after admission by the PRESEV2 score at arrival. Validation of a Predictive Score of Acute Chest Syndrome (Presev2) associates a categorical pain score of the spine /or pelvis and 3 biological parameters: Reticulocytes, Leucocytes and Hemoglobin. ACS is defined by crepitant or bronchial breathing or the association of new radiologic infiltrate and chest pain Inclusion criteria: - Children (>2 years) and adults - Male and Female - Homozygous SCD patients - The patient can only be included once - VOC admitted at the emergency unit (a severe VOC is defined as pain or tenderness affecting at least one part of the body (e.g. limbs, ribs, sternum, head (skull), spine and/or pelvis) that required hospitalization and opioids (level 3), and is not attributable to other causes. - Patient has health care insurance (in Europe) - Written consent given after being informed of the purpose, progress and potential risks Exclusion criteria: - No inaugural Acute Chest Syndrome - Homeless patients - Deprived of their liberty by a court or administrative order or under guardianship - Unable to understand the purpose and conditions of carrying out the study, unable to give consent STUDY SCHEDULE Screening and inclusion once patients are admitted at the accident and emergency department or medical day unit. Inclusion visit (day 1) Once admitted at the accident and emergency department, the patient will be informed about the protocol and asked to participate in the study. Informed consent will be obtained according to local regulations by signing the informed consent form. The inclusion and non-inclusion criteria will be verified. Demographic data, current and previous treatments taken within one month, and medical history will be recorded. The following parameters of the score will be collected: Reticulocytes and/or leucocytes counts, urea (mmol/L) and Categorical pain score. The Score is adjusted with Hydroxyurea treatment (Yes/No) and Hb level (g/dL). Plasmodium falciparum test will be performed only in Africa. Hemoculture if fever (>38°C) is recorded within the 2 first days after admission. Temperature, Blood pressure, Oxygen saturation, Respiratory rate, Visual analogue score will be recorded. STUDY DURATION Inclusion period: 2 years Per patient: 15 days Total duration of the study: 2 years


Recruitment information / eligibility

Status Recruiting
Enrollment 800
Est. completion date December 31, 2023
Est. primary completion date December 31, 2023
Accepts healthy volunteers No
Gender All
Age group 2 Years and older
Eligibility Inclusion Criteria: - Inclusion criteria: - Children (>2 years) and adults - Male and Female - Homozygous SCD patients - VOC admitted at the emergency unit (a severe VOC is defined as pain or tenderness affecting at least one part of the body (e.g. limbs, ribs, sternum, head (skull), spine and/or pelvis) that required hospitalization and opioids (level 3), and is not attributable to other causes. - Patient has health care insurance (in Europe) - Written consent given after being informed of the purpose, progress and potential risks Exclusion criteria: - No inaugural Acute Chest Syndrome - Homeless patients - Deprived of their liberty by a court or administrative order or under guardianship - Unable to understand the purpose and conditions of carrying out the study, unable to give consent

Study Design


Related Conditions & MeSH terms


Locations

Country Name City State
France Henri Mondor Hospital Creteil

Sponsors (3)

Lead Sponsor Collaborator
Soutien aux Actions contre les Maladies du Globule Rouge ADDMEDICA SASA, Pierre Fabre Laboratories

Country where clinical trial is conducted

France, 

Outcome

Type Measure Description Time frame Safety issue
Primary Primary Outcome Measure of Validation of a Predictive Score of Acute Chest Syndrome The primary outcome mesure is the occurrence of an ACS defined by crepitant or bronchial breathing or the association of new radiologic infiltrats and chest pain during the first 15 days of hospitalization for Vaso Occlusive Crisis 2 years
Secondary Secondary Outcome Measures: Validation of a Predictive Score of Acute Chest Syndrome Association of the PRESEV 2 score with the following parameters collected for each patient:
The number of days of hospitalization
Blood transfusion requirement
The number of hospitalization in intensive care unit
Death
2 years
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