Acute Chest Syndrome Clinical Trial
— Presev2Official title:
Validation of a Predictive Score of Acute Chest Syndrome
Vaso-Occlusive Crisis (VOC), the most common manifestation of sickle cell disease (SCD), is the first cause of death, particularly when complicated by an acute chest syndrome (ACS). The PRESEV score could help the physicians to better manage VOC and could be used for future therapeutic trials. This predictive score of secondary ACS has to be validated in a multicenter international study.
Status | Recruiting |
Enrollment | 800 |
Est. completion date | December 31, 2023 |
Est. primary completion date | December 31, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 2 Years and older |
Eligibility | Inclusion Criteria: - Inclusion criteria: - Children (>2 years) and adults - Male and Female - Homozygous SCD patients - VOC admitted at the emergency unit (a severe VOC is defined as pain or tenderness affecting at least one part of the body (e.g. limbs, ribs, sternum, head (skull), spine and/or pelvis) that required hospitalization and opioids (level 3), and is not attributable to other causes. - Patient has health care insurance (in Europe) - Written consent given after being informed of the purpose, progress and potential risks Exclusion criteria: - No inaugural Acute Chest Syndrome - Homeless patients - Deprived of their liberty by a court or administrative order or under guardianship - Unable to understand the purpose and conditions of carrying out the study, unable to give consent |
Country | Name | City | State |
---|---|---|---|
France | Henri Mondor Hospital | Creteil |
Lead Sponsor | Collaborator |
---|---|
Soutien aux Actions contre les Maladies du Globule Rouge | ADDMEDICA SASA, Pierre Fabre Laboratories |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Primary Outcome Measure of Validation of a Predictive Score of Acute Chest Syndrome | The primary outcome mesure is the occurrence of an ACS defined by crepitant or bronchial breathing or the association of new radiologic infiltrats and chest pain during the first 15 days of hospitalization for Vaso Occlusive Crisis | 2 years | |
Secondary | Secondary Outcome Measures: Validation of a Predictive Score of Acute Chest Syndrome | Association of the PRESEV 2 score with the following parameters collected for each patient:
The number of days of hospitalization Blood transfusion requirement The number of hospitalization in intensive care unit Death |
2 years |
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