Impact of Continuous Positive Airway Pressure on the Treatment of Acute Asthma Exacerbation

Acute Asthma Clinical Trial

Official title:

Impact of Continuous Positive Airway Pressure on the Treatment of Acute Asthma Exacerbation

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01403467
• Other study ID #: 02-52-28
• Secondary ID: MURA2009/1239
• Status: Completed
• Phase: Phase 4
• First received: July 25, 2011
• Last updated: July 26, 2011
• Start date: April 2009
• Est. completion date: January 2011

Study information

• Verified date: December 2010
• Source: Ramathibodi Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Thailand:Mahidol University
• Study type: Interventional

Clinical Trial Summary

This current study aimed to demonstrate the effectiveness of the addition of CPAP to the current conventional therapy in terms of airway obstruction improvement in acute asthma patients.

Description:

Continuous positive airway pressure (CPAP) is widely used in providing ventilator support. However, its role in an acute asthmatic attack is uncertain. The purpose of this study was to compare the efficacy of CPAP when used in addition to conventional therapy with conventional therapy alone in the management of acute asthma exacerbation.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 86
• Est. completion date: January 2011
• Est. primary completion date: January 2010
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 19 Years to 75 Years

Eligibility

Inclusion Criteria:

• aged over 18 years

• known asthmatic patients visiting ED with acute exacerbation

• had given their written informed consent.

Exclusion Criteria:

• smoking history

• chronic obstructive pulmonary disease

• required intubation

• instability of hemodynamic or arrhythmia

• unable to perform PEFR

• facial abnormality

• pulmonary infiltration

• pregnancy.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Acute Asthma
• Asthma

Intervention

Device:
• Continuous positive airway pressure
CPAP 8 cmH2O

Locations

Country	Name	City	State
Thailand	Ramathibodi Hospital	Bangkok

Sponsors (1)

Lead Sponsor	Collaborator
Ramathibodi Hospital

Country where clinical trial is conducted

Thailand, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	an improvement in PEFR, as % predicted		75 mins	No