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Acute Asthma clinical trials

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NCT ID: NCT04016220 Recruiting - Acute Asthma Clinical Trials

Nebulized Budesonide Combined With Systemic Corticosteroid in Acute Severe Asthma

Start date: May 20, 2019
Phase: Phase 1
Study type: Interventional

Our study is a prospective double-blind randomized study performed in the Emergency Department (ED). The objective of our study was to demonstrate the additive effect of high and repeated doses of inhaled budesonide combined with the standard treatment of acute asthma in adult managed in the ED

NCT ID: NCT03698630 Completed - Asthma Clinical Trials

Single Dose Oral Dexamethasone Versus Multi-dose Prednisolone in the Treatment of Acute Exacerbations of Asthma in Children

Start date: July 6, 2011
Phase: Phase 4
Study type: Interventional

A trial to investigate if a single dose of the oral corticosteroid, Dexamethasone is as effective in treating exacerbations of asthma in children as 3 days of treatment with another oral corticosteroid, Prednisolone

NCT ID: NCT03369119 Completed - Acute Asthma Clinical Trials

Effect of Addition Oral Montelukast to Standard Treatment in Acute Asthma in Hospitalized Preschool Children

Start date: August 2011
Phase: Phase 4
Study type: Interventional

Leukotriene receptor antagonists (LTRAs) are well established in the management of outpatient asthma. Montelukast is a potent, specific, orally active, cysteinyl leukotriene receptor antagonist with a rapid onset of action.However, there is very little information as to their role in acute asthma exacerbations. The purpose of this study is to determine if adding oral montelukast to the maximal standard treatment in children hospitalized for acute asthma has any additive benefit.

NCT ID: NCT01868113 Completed - Bacterial Pneumonia Clinical Trials

Inhaled Corticosteroids in U-5 Children With Acute Respiratory Infection in Uganda: A Randomised Trial

ICS
Start date: December 2012
Phase: Phase 3
Study type: Interventional

The purpose of this study is to find out whether adjunct treatment with inhaled corticosteroids lead to faster improvement and reduce mortality of children under 5 years of age admitted to hospital with ALRI.

NCT ID: NCT01695031 Completed - Acute Asthma Clinical Trials

Feasibility of an ED Initiated Online Asthma Management Program for Urban Teens

PuffCityED
Start date: October 2012
Phase: N/A
Study type: Interventional

The objective of this study is to determine the feasibility of conducting a randomized controlled trial to evaluate the effectiveness of an online, Emergency Department-initiated asthma management intervention designed to reduce asthma-related morbidity among urban teenagers aged 13-19 years with uncontrolled asthma. The study will examine issues around recruitment, participant compliance with the study protocol, Internet access, and attrition. Investigators will first develop a protocol for recruiting 13-19 year old patients with acute asthma into an ED-initiated pilot trial of an online asthma management program, describing recruitment and refusal rates. Investigators will measure participant compliance with the pilot study protocol including 4 online sessions and a 6 month survey. Investigators will also measure compliance of the participants parents at baseline and a six month follow up. Investigators will then use pilot study results to describe the intervention effect on selected outcomes including ED visits, asthma control as measured by Asthma Control Questionnaire, functional limitations, quality of life, and behavior change.

NCT ID: NCT01429415 Completed - Acute Asthma Clinical Trials

Magnesium Nebulization Utilization in Management of Pediatric Asthma

MAGNUMPA
Start date: September 26, 2011
Phase: Phase 2
Study type: Interventional

Acute asthma is the most common cause of pediatric hospitalizations. While the investigators know that repeat inhalations of ß2 agonists and ipratropium with early oral steroids substantially reduce hospitalizations, many children are resistant to this standard initial therapy. About a third of children remaining in moderate to severe distress after standard therapy are admitted to hospital and comprise 84% of pediatric acute asthma hospitalizations. Finding safe, non-invasive, and effective strategies to treat children resistant to standard therapy would substantially decrease hospitalizations resulting in considerable health care savings and reduction of the psycho-social burden of the disease. While studies of magnesium sulfate (Mg) given intravenously (IV) suggest that this agent can reduce hospitalizations in both adults and children resistant to standard initial therapy Nebulization is an alternate route for administering Mg. This route has the advantage of being non-invasive and is likely much safer due to lower systemic delivery. Direct delivery via nebulization allows higher Mg concentrations at the target site, the lower airways, with a smaller total drug dose. The investigators propose to conduct a properly designed study to clarify the role of nebulized Mg.

NCT ID: NCT01403467 Completed - Acute Asthma Clinical Trials

Impact of Continuous Positive Airway Pressure on the Treatment of Acute Asthma Exacerbation

Start date: April 2009
Phase: Phase 4
Study type: Interventional

This current study aimed to demonstrate the effectiveness of the addition of CPAP to the current conventional therapy in terms of airway obstruction improvement in acute asthma patients.

NCT ID: NCT01304901 Completed - Asthma Clinical Trials

Effect of Addition of Single Dose of Oral Montelukast to Standard Treatment in Acute Asthma in Preschool Children.

Start date: April 2010
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine if adding single dose of oral montelukast to the standard treatment of systemic glucocorticoids plus short acting beta-2 agonist for treatment of acute wheezing provide additional clinical benefit in the emergency room.

NCT ID: NCT01196377 Completed - Acute Asthma Clinical Trials

Optimal Albuterol Regimens for Acute Asthma Exacerbations: DBRCT Pilot Study

OARS
Start date: September 2010
Phase: N/A
Study type: Interventional

Our overall objective is to model a pediatric Acute Asthma Clinical Decision Rule (ADR) for personalized medicine by identification of treatment-response phenotypes that are important determinants of outcome. The Specific Aim of this study is to determine the feasibility of this approach by enrolling a pilot cohort of 16 participants in this DBRCT of 4 different albuterol treatment regimens, 2 of which will use 10mg/hr and 2 of which will use 25mg/hr. Within these dosages there will be a pulsed-treatment regimen and a continuous regimen.

NCT ID: NCT01079000 Completed - Acute Asthma Clinical Trials

Emergency Department (ED)-Directed Interventions to Improve Asthma Outcomes

Start date: June 2012
Phase: N/A
Study type: Interventional

The purpose of this study is to determine if evidence-based guidance on follow-up care and self-management provided to PCPs and patients, respectively, reduces relapses within 90 days for acute asthma (primary outcome). Secondary outcomes will include follow-up visits with the primary care provider, patients' quality of life and cost-effectiveness indicators.