Acute Asthma Clinical Trial
Official title:
Heliox and Posture Optimize Action of Nebulization With Bronchodilators for Asthma Attacks. Randomized Trial.
The purpose of this study is to verify that nebulization with bronchodilators associated with heliox gas (helium + oxygen) and the posture of a leaning forward truck is effective in patients with an asthma attack.
When associated with inhaled bronchodilators, the heliox, a mixture of helium and oxygen in
obstructive lung diseases with asthma, reduces the turbulence of airflow despite high rates,
due to its low density.
Although the first report of the use of heliox in the treatment of asthma dating to 1935,
few controlled studies are available clarify the impact of the use of heliox in hospital
admission of patients with acute asthma attacks refractory to standard treatment.
The severe airflow obstruction, observed in cases of acute asthma, also leads to lung
hyperinflation that favors the increase of respiratory work by increasing the load for the
inspiratory muscles by placing them at a mechanical disadvantage.
Various body positions were studied relating them to muscle activity with mechanical
disadvantage. These studies suggest that the influence posture acts mainly in the position
of the diaphragm, thus, increasing the stress related to other muscles such as the
abdominals and the effect of gravity on these.
This study aims to: assess the efficiency of the positioning body associated with
nebulization with bronchodilators carried by heliox during acute severe asthma in adults,
using as the primary outcomes FEV1, FVC and PEF and secondary outcomes as the Borg scale,
inspiratory capacity, RR, HR and SpO2.
;
Allocation: Randomized, Intervention Model: Factorial Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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