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NCT05843630 Clinical Trial

Radiomic Modeling in Differentiating Uncomplicated From Complicated Acute Appendicitis

Acute Appendicitis Clinical Trial

Official title:
Development and Validation of an Individualized Nomogram to Differentiate Uncomplicated From Complicated Acute Appendicitis in Adults: a Multicenter Study

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05843630
Other study ID # PLAGH202304
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date January 3, 2023
Est. completion date December 3, 2023

Study information
Verified date May 2023
Source Chinese PLA General Hospital
Contact LI LI
Phone 13210613213
Email 1192225348@qq.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Non-operative management (NOM) with antibiotics may be a safe alternative to surgery for uncomplicated appendicitis, but preoperative differentiation between uncomplicated and complicated appendicitis is challenging. The study aimed to develop a clinical-radiomics nomogram to distinguish uncomplicated from complicated appendicitis.

Recruitment information / eligibility
Status Recruiting
Enrollment 250
Est. completion date December 3, 2023
Est. primary completion date June 3, 2023
Accepts healthy volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Pathologically diagnosed as acute appendicitis after appendectomy between January 2021 and December 2022. Exclusion Criteria: - age less than 18 years (no upper age limit); - without CT examination within a week before surgery; - difficult to outline the contours of the appendix due to inflammatory exudate; - lack of clinical information.

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• without
without

Locations
Country Name City State
China Chinese PLA General Hospital First Medical Center Beijing

Sponsors (1)
Lead Sponsor Collaborator
Kecheng Zhang

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary Accuracy of clinical-radiomic model for differentiating complicated from uncomplicated appendicitis ROC curve will be plotted and the area under ROC curve will be compared January 2021 to December 2022
See also
  Status Clinical Trial Phase
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Completed NCT04387370 - The Use of the Hem-o-lok Clip in Appendectomy: Single or Double?
Completed NCT04649996 - Variation in Acute Appendicitis During COVID-19 Pandemic in Italy
Completed NCT04030741 - Non-operative Treatment of Acute Non-perforated Appendicitis Phase 2/Phase 3
Recruiting NCT04860570 - Are Double-ring Wound-edge Protectors Effective for Preventing Superficial Surgical Site Infection After Open Appendectomy?
Withdrawn NCT05724628 - Non-operative vs. Operative Management of Acute Appendicitis in Vulnerable Patient Populations Phase 1
Completed NCT01024439 - Transumbilical Single Incision Versus Conventional Three Incisions Laparoscopic Appendicectomy N/A
Completed NCT02714023 - Water And Saline Head-to-head In The Blinded Evaluation Study Trial N/A
Active, not recruiting NCT03324165 - Comparing Proposed Algorithm and Current Practice in the Evaluation of Suspected Appendicitis N/A
Active, not recruiting NCT01022567 - Appendicectomy Versus Antibiotics in the Treatment of Acute Uncomplicated Appendicitis N/A
Not yet recruiting NCT06051825 - Diagnostic Importance of the C-reactive Protein From Blood and Saliva in Children With Acute Appendicitis
Not yet recruiting NCT06059365 - Clinical Trial for a Outpatient Clinical Management for Complicated Acute Appendicitis N/A
Recruiting NCT04947748 - Short Post-operative Antibacterial Therapy in Complicated Appendicitis: Oral Versus Intravenous N/A
Terminated NCT04207645 - Modification and Validation of the RIPASA Score for Diagnosis of Acute Appendicitis
Completed NCT04615728 - MANAGEMENT OF APPENDICITIS DURING THE COVID-19 PANDEMIC
Not yet recruiting NCT02789865 - Clinical Trial Comparing ERAT vs Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis Phase 2
Completed NCT02731924 - Point of Care Ultrasound for Evaluation of Suspected Appendicitis in the Emergency Department
Completed NCT05104346 - Presentation and Outcomes of Acute Appendicitis During COVID Pandemic N/A
Completed NCT03886896 - Intravenous Lidocaine in Children Undergoing Laparoscopic Appendectomy Phase 4
Not yet recruiting NCT01720082 - Laparoscopic Appendectomy by Multi-port vs Single Port. Phase 3