Non Contrast CT in Acute Appendicitis

Acute Appendicitis Clinical Trial

Official title:

Diagnostic Accuracy of Non-Contrast Computed Tomography in Correlation With Ultrasound in Detecting Acute Appendicitis in Adults

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05815446
• Other study ID #: CT in acute appendicitis
• Status: Not yet recruiting
• Start date: April 20, 2023
• Est. completion date: December 30, 2023

Study information

• Verified date: April 2023
• Source: Assiut University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

To evaluate Diagnostic accuracy of Non-contrast CT in correlation with ultrasound in diagnosis of acute appendicitis in adults

Description:

Acute appendicitis is a prevalent cause of abdominal pain, with an estimated lifetime risk of 7 to 9%.[1] Diagnosing appendicitis on CT has a sensitivity and specificity of 87% and 76%, respectively. Classically, diagnosis of acute appendicitis is by identifying an enlarged appendix (greater than 6 mm in diameter) .

Some studies suggest using a cut-off value of over 7 mm to improve the prognostic capability of CT.

On the other hand, appendicitis is regularly diagnosed using radiology studies. In fact, imaging is often the deciding factor between operative and non-operative management. Though the diagnosis can be clinical following a thorough history and physical, imaging is regularly employed to confirm the diagnosis in question. The most commonly used radiographic study is the CT scan, given its speed, sensitivity, and specificity. US is also relatively useful modality to diagnose acute appendicitis, it has its limitations. Ultrasound is highly operator dependent and tends to work best on individuals with less fat and muscle content in their abdomen (i.e., children). Currently, the negative appendectomy is less than 12% in men but can be up to 33% in women; accurate imaging studies could reduce the number of unnecessary surgeries performed on patients. It is, therefore, essential to know which study will provide the clinician with the most accurate information for their specific clinical scenario.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 78
• Est. completion date: December 30, 2023
• Est. primary completion date: December 1, 2023
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• Adult patient (male or female) with clinical suspicion of acute appendicitis .

Exclusion Criteria:

• pregnant ladies and patients with history of appendectomy

Related Conditions & MeSH terms

• Acute Appendicitis
• Acute Disease
• Appendicitis

Intervention

Device:
• CT
NON CONTASR COMPUTED TOMOGRAPHY

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

References & Publications (2)

Cohen CI. A case report: periodontal surgery in Parkinsonism utilizing intravenous sedation. N Y State Dent J. 1978 Jan;44(1):19. No abstract available. — View Citation

Drazen JM. Asthma therapy with agents preventing leukotriene synthesis or action. Proc Assoc Am Physicians. 1999 Nov-Dec;111(6):547-59. doi: 10.1046/j.1525-1381.1999.t01-1-99242.x. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	accuracy of non contrast CT in correlation with ultrasound in acute appendicitis .	Diagnostic Accuracy of Non-Contrast Computed Tomography in Correlation with Ultrasound in Detecting Acute Appendicitis in Adults.	baseline