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Acute Appendicitis clinical trials

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NCT ID: NCT04117061 Recruiting - Acute Appendicitis Clinical Trials

Optimizing the Diagnosis of Acute Appendicitis

OPTIMA
Start date: December 1, 2018
Phase: N/A
Study type: Interventional

Aim of the study: to identify the signs of acute appendicitis delta signs - clinical, laboratory or ultrasound signs, whose change (delta) would allow to identify or deny the diagnosis of acute appendicitis without a computed tomography examination and thus to lower computed tomography rates.

NCT ID: NCT04030741 Completed - Acute Appendicitis Clinical Trials

Non-operative Treatment of Acute Non-perforated Appendicitis

Start date: September 1, 2018
Phase: Phase 2/Phase 3
Study type: Interventional

Gold Standard treatment of appendicitis is appendectomy but non-operative treatment of non-perforated appendicitis with antibiotics is also under trial. Although appendectomy is curative but it is an invasive procedure done under general anesthesia with different risks and complications during and after operation, leading to disturbance of child daily routines and activities. Reported rates of perioperative complications are from 5% - 10%, with serious complications occurring in 1% to 7% of patients. Children presenting with acute (<2 days) right iliac fossa pain with pediatric appendicitis score >7, with none of the following on ultrasonography: abscess formation, or loss of the echogenic sub-mucosal layer of the appendix or presence of an appendicolith or periappendiceal fluid collection will be labeled as having appendicitis. After diagnosis we divided the patients into two groups.patients in group A will be treated with antibiotics and appendectomy is done for group B patients.

NCT ID: NCT03886896 Completed - Postoperative Pain Clinical Trials

Intravenous Lidocaine in Children Undergoing Laparoscopic Appendectomy

Start date: March 22, 2019
Phase: Phase 4
Study type: Interventional

Intravenous lidocaine - a potent local anesthetic with analgesic and anti-inflammatory properties has been shown to be an effective adjunct that reduces intra and postoperative opioid consumption and facilitates pain management in adults. In children population promising but limited evidence is available. The study was planned to evaluate the efficacy of continuous intravenous infusion of lidocaine to reduce opioid consumption during and after laparoscopic appendectomy in children.

NCT ID: NCT03754777 Completed - Acute Appendicitis Clinical Trials

Modified Enhanced Recovery Program in Emergency Surgery (MERES)

MERES
Start date: July 1, 2017
Phase: N/A
Study type: Interventional

Laparoscopic appendectomy (LA) is a widespread surgical procedure. Patients may develop considerable postoperative pain and dyspepsia resulting in prolong in-hospital stay. Almost 10% of patients develop postoperative complications. Enhanced recovery after surgery (ERAS) program has proven its effectiveness in elective surgery and can theoretically improve outcomes of LA. To date there is no ERAS program for LA. The aim of the study was to investigate the safety and efficacy of a modified ERAS protocol in LA.

NCT ID: NCT03750032 Completed - Acute Appendicitis Clinical Trials

Technical Modifications of Appendicular Stump Closure During Laparoscopic Appendectomy

CAS
Start date: June 1, 2018
Phase: N/A
Study type: Interventional

Laparoscopic appendectomy (L-APPE) presents a golden standard in the treatment of acute appendicitis nowadays. However, there are ongoing controversies regarding the ideal technique of appendicular stump closure during L-APPE in the published literature. Several technical modifications of appendicular stump closure are available at the present - closure using endoloop, endostapler or Hem-o-lock clips. The aim of the proposed project (CAS study) is to compare medical and economic outcomes of patients undergoing L-APPE with different methods of appendicular stump closure (endostapler, endoloop and Hem-o-lock clips).

NCT ID: NCT03687502 Completed - Acute Appendicitis Clinical Trials

The Role of Contrast Enhanced Ultrasound in Appendicitis

Start date: January 4, 2019
Phase: Phase 2
Study type: Interventional

This study seeks to determine the efficacy of Contrast Enhanced Ultrasound (CEUS) in improving the diagnosis of acute appendicitis in children, when compared to the standard grey-scale ultrasound.

NCT ID: NCT03643718 Recruiting - Trauma Clinical Trials

Web-based International Register of Emergency Surgery and Trauma

WIRES-T
Start date: July 2020
Phase:
Study type: Observational [Patient Registry]

The WIRES-T project (Web-based International Registry of Emergency General Surgery and Trauma) has been set up to allow to all the EGS (Emergency General Surgery) and Trauma surgeons to register their activity and to obtain a worldwide register of traumatic and non traumatic surgical emergencies. This will give the opportunity to evaluate results on a macro-data basis and to give index allowing stratifying, evaluating and improving the outcomes.

NCT ID: NCT03504878 Completed - Acute Appendicitis Clinical Trials

Cost-effectiveness Analysis and Case-based Payment Norm Modeling on Appendicitis Patients at Hanoi Medical University Hospital

Start date: January 1, 2011
Phase:
Study type: Observational

In the world, there are several studies comparing the cost-effectiveness between laparoscopic appendectomy and open appendectomy. But in Vietnam, health economics studies for acute appendicitis surgery in general and laparoscopic appendectomy in particular has hardly been available, and in the context of reform of the financial mechanism for payment, questions about the cost-effectiveness between the two surgical methods are particularly concerned. Therefore, we conducted a study "Cost-effectiveness analysis and case-based payment norm modeling in patients with appendectomy at Hanoi Medical University Hospital"

NCT ID: NCT03450642 Completed - Acute Appendicitis Clinical Trials

Complement Diagnosis of Acute Appendicitis

CDAA
Start date: January 2012
Phase: N/A
Study type: Observational

Acute appendicitis is a common condition requiring urgent surgery but is often difficult to distinguish from other non-surgical conditions such as urinary infections, pelvic inflammatory disease and non-specific abdominal pain. Delay in diagnosis can result in significant morbidity and potential mortality. Currently, there is no one diagnostic test available and raised inflammatory markers such as C-reactive protein (CRP) and White Blood Count (WBC) along with an evolving clinical picture, help guide management. However, these markers are slow to respond to inflammation and are non-specific for appendicitis. The Complement cascade is an immune response to inflammation and infection involving three pathways which activate a number of proteins in the blood. Monitoring the absolute levels of these proteins should provide a faster and differential diagnostic test. The investigators propose a pilot trial to measure concentrations of Complement cascade activation biomarkers in the blood during hospital admissions for acute right lower abdominal pain, a symptom of appendicitis. Further, analysis of the differential Complement cascade pathway activation could potentially identify underlying pathology allowing the clinicians to target therapies.

NCT ID: NCT03414853 Completed - Abdominal Pain Clinical Trials

Free Text Prediction Algorithm for Appendicitis

Start date: December 4, 2017
Phase:
Study type: Observational

Computer-aided diagnostic software has been used to assist physicians in various ways. Text-based prediction algorithms have been trained on past medical records through data mining and feature analysis. Currently, all text-based machine learning prediction problem models have been built on extracted data with no research completed on free text based prediction algorithms. This study aims to determine the accuracy of a free text prediction algorithm in predicting the probability of appendicitis in patients presenting to the Emergency Department with abdominal pain and gastrointestinal symptoms.